PTPN11 / PTP2C antibody

Principal name

PTPN11 / PTP2C antibody

Alternative names for PTPN11 / PTP2C antibody

SHPTP2, PTP-1D, PTP-2C, SH-PTP2, SHP-2, Shp2, SH-PTP3, Tyrosine-protein phosphatase non-receptor type 11, Protein-tyrosine phosphatase 1D, Protein-tyrosine phosphatase 2C

SwissProt ID

P35235 (Mouse), P41499 (Rat), Q06124 (Human), Q06124-2, Q90687 (Chick)

Gene ID

5781 (PTPN11)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Mky (Monkey), Por (Porcine), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C), Flow Cytometry (F)

Background of PTPN11 / PTP2C antibody

SHP (also designated short heterodimer partner and small heterodimer partner) is an orphan nuclear receptor containing the dimerization and ligandbinding domains found in other nuclear receptors but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues including fetal liver and adrenal gland, adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARγ. SHP interacts with nuclear receptors including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function via competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NF-κB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NF-κB. Lastly, negative feedback regulation of a hepatic bile acid transporter NTCP is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions.

General readings

Ferjoux G, et al. (2003) Mol Biol Cell. 2003; 14(9): 3911-3928.
Shi ZQ, et al. (2000) Mol Cell Biol ; 20(5): 1526-1536.
Li C, Friedman JM. (1999) Proc Natl Acad Sci U S A ; 96(17): 9677-9682
Mańes S, et al. (1999) Mol Cell Biol ; 19(4): 3125-3135.
Oh ES, et al. (1999) Mol Cell Biol; 19(4): 3205-3215.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN11 / PTP2C antibody

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-PTPN11 monoclonal antibody. Mouse IgG2a OTI3F2 Purified Can, Hu F, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

PTPN11 / PTP2C (576-593) antibody

Human bone marrow stained with Anti-SH-PTP2, cat# AP15775PU Rabbit Purified Hu, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

PTPN11 / PTP2C (576-593) antibody

Human bone marrow stained with Anti-SH-PTP2, cat# AP15775PU Rabbit Purified Hu, Ms, Rt P
1 ml / €520.00
  Acris Antibodies GmbH

PTPN11 / PTP2C (576-593) antibody

Human bone marrow stained with Anti-SH-PTP2, cat# AP15775PU Rabbit Purified Hu, Ms, Rt P
0.1 ml / €190.00
  Acris Antibodies GmbH

PTPN11 / PTP2C antibody

Western blot analysis of PTPN11 (arrow) using rabbit polyclonal SHP2 Antibody (RB07283). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PTPN11 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C (C-term) antibody

TA302607 staining (2µg/ml) of human muscle lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C (C-term) antibody

Western blot analysis of SHP2 in mouse skeletal muscle tissue lysate with SHP2 antibody at (A) 0.5, (B) 1 and (C) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C (N-term) antibody

Western blot analysis of SHP2 in mouse skeletal muscle tissue lysate with SHP2 antibody at (A) 0.5 and (B) 1 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C antibody

Gel: 10%SDS-PAGE, Lysate: 40 µg, Lane: NIH/3T3 cells, Primary antibody: PTPN11 Antibody at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C antibody

Predicted band size: 68 kDa . Positive control: NIH/3T3 and hela cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: NIH/3T3 cell lysate Lane2: Hela cell lysate Lysates: 40 ug per lane Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C antibody

Western blot analysis of extracts from COS7 cells, using SH-PTP2 antibody (#TA326255).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C antibody

Western blot analysis of SHP-2 expression in A431 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C antibody

Western blot analysis of SHP-2 expression in A431 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN11 / PTP2C antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTPN11 (RC220029, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTPN11. Mouse IgG1 OTI2F4 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTPN11 / PTP2C antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PTPN11 (RC220029, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PTPN11. Mouse IgG1 OTI1F7 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

PTPN11 / PTP2C pTyr542 antibody

Immunohistochemical analysis of paraffin-embedded
human breast carcinoma tissue, using SHP-2 (Phospho-Tyr542) antibody Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

PTPN11 / PTP2C pTyr542 antibody

Immunohistochemical analysis of paraffin-embedded
human breast carcinoma tissue, using SHP-2 (Phospho-Tyr542) antibody Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €240.00
  Acris Antibodies GmbH

PTPN11 / PTP2C pTyr580 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-2 antibody (AP02544PU-S; AP02544PU-N). Rabbit Aff - Purified Hu P
0.1 ml / €320.00
  Acris Antibodies GmbH

PTPN11 / PTP2C pTyr580 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-2 antibody (AP02544PU-S; AP02544PU-N). Rabbit Aff - Purified Hu P
50 µl / €240.00
  Acris Antibodies GmbH

PTPN11 / PTP2C antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-2 antibody. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

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