PTPN13 antibody

Principal name

PTPN13 antibody

Alternative names for PTPN13 antibody

PTP-BAS, PNP1, PTP1E, PTP-E1, PTPL1, FAP1, Tyrosine-protein phosphatase non-receptor type 13, Protein-tyrosine phosphatase 1E,Protein-tyrosine phosphatase PTPL1, Fas-associated protein-tyrosine phosphatase 1

SwissProt ID

Q12923 (Human), Q64512 (Mouse)

Gene ID

5783 (PTPN13), 19249 (Ptpn13)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of PTPN13 antibody

FAP-1 (also known as Fas-associated phosphatase-1, PTPN13, PTP-BAS, hPTPIE, and PTPL1) is a member of the protein tyrosine phosphatase (PTP) family (reviewed in Meinhold-Heerlein et al, 2001; Savaskan et al, 2005; Foehr et al, 2005; and Ivanov et al, 2006). PTPs are enzymes that catalyze the removal of a phosphate group attached to a tyrosine residue. Most intracellular sigling involves reversible phosphorylation events; therefore, PTPs are central to the dymic regulation of sigling cascades that underlie cell functions. For example, PTPs play key roles in regulating cell growth, differentiation, proliferation, inflammation, and oncogenic transformation. PTPs are emerging as a promising class of sigling targets for diseases such as cancer, neurodegeneration, diabetes, and inflammation. A key challenge is to identify specific PTPs that are invovled in a disease process and develop therapeutics to modulate the PTP. FAP-1 phosphatase is thought to be important in the Fas sigling pathway. FAP-1 binds to the cytosolic tail of the Fas receptor (Apo1, CD95) and inhibits Fas-induced apoptosis. Increased FAP-1 protein levels in some tumor cell lines and tumor tissues correlates with resistance to Fas-mediated apoptosis. In general, FAP-1 expression has been found to be highest in cell lines and tissues that are relatively resistant to Fas-mediated apoptosis. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line which is consistent with an inhibitory effect of FAP-1 on Fas sigl transductions. Additiolly, FAP-1 expression correlates with Fas resistant in ovarian cancer cell lines and FAP-1 is commonly expression in ovarian cancers. Human Fas has a putative consensus tyrosine phosphorylation site (Tyrosine 275) suggesting that Fas surface expression or sigling may be regulated by phosphorylation. FAP-1 has been shown to directly bind to Fas and may dephosphorylate Fas as part of the down regulation of the apoptotic pathway. It is thought that development of therapeutics to inhibit FAP-1 may increase the ability of tumor cells with upregulated FAP-1 to undergo apoptosis. FAP-1 is a large approx. 270 kDa protein. Multiple altertively spliced FAP-1 transcript variants which encode distinct proteins have been reported, including shorter forms. Please see Application Notes section for additiol details on FAP-1 isoforms.

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN13 (2451-2466) antibody

  FAP-1 / PTPN13 Rabbit Polyclonal (aa2451-2466) Antibody  
Anti-PTPN13 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit Purified Hu E, P
50 µg / €400.00
  OriGene Technologies, Inc.

PTPN13 antibody

  Rabbit Polyclonal PTPN13/PTPL1 Antibody  
Western Blot: PTPN13 Antibody [TA336328] - analysis of FAP-1 using this antibody. In ovarian carcinoma cell lines FAP-1 expression was detected in SK-OV-3 and OVCAR-3, but not in BG-1 or HEY. Human Jurkat T and 293 kidney cell lines were used as negative Rabbit Purified Hu C, ICC/IF, IP, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

PTPN13 antibody

Immunohistochemical analysis in paraffin-embedded human breast carcinoma tissue using PTPN13 / FAP-1 antibody (Cat.-No. AP06116PU-N). Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PTPN13 (2290-2491) antibody

Human Kidney (formalin-fixed, paraffin-embedded) stained with PTPN13 antibody AP22687PU-N at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu P
0.25 ml / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

PTPN13 - human gene knockout kit via CRISPR

PTPN13 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PTPN13 - human gene knockout kit via CRISPR

PTPN13 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PTPN13 - human gene knockout kit via CRISPR

PTPN13 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PTPN13 - human gene knockout kit via CRISPR

PTPN13 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptpn13 - mouse gene knockout kit via CRISPR

Ptpn13 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ptpn13 - mouse gene knockout kit via CRISPR

Ptpn13 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptpn13 - mouse gene knockout kit via CRISPR

Ptpn13 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptpn13 - mouse gene knockout kit via CRISPR

Ptpn13 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

PTPN13 overexpression lysate

PTPN13 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PTPN13 (Myc-DDK tagged) - Human protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (PTPN13), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, PTPN13 (Myc-DDK tagged) - Human protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) (PTPN13), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,280.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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