PTPN13 antibody

Principal name

PTPN13 antibody

Alternative names for PTPN13 antibody

PTP-BAS, PNP1, PTP1E, PTP-E1, PTPL1, FAP1, Tyrosine-protein phosphatase non-receptor type 13, Protein-tyrosine phosphatase 1E,Protein-tyrosine phosphatase PTPL1, Fas-associated protein-tyrosine phosphatase 1

SwissProt ID

Q12923 (Human), Q64512 (Mouse)

Gene ID

5783 (PTPN13)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Chicken

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of PTPN13 antibody

FAP-1 (also known as Fas-associated phosphatase-1, PTPN13, PTP-BAS, hPTPIE, and PTPL1) is a member of the protein tyrosine phosphatase (PTP) family (reviewed in Meinhold-Heerlein et al, 2001; Savaskan et al, 2005; Foehr et al, 2005; and Ivanov et al, 2006). PTPs are enzymes that catalyze the removal of a phosphate group attached to a tyrosine residue. Most intracellular sigling involves reversible phosphorylation events; therefore, PTPs are central to the dymic regulation of sigling cascades that underlie cell functions. For example, PTPs play key roles in regulating cell growth, differentiation, proliferation, inflammation, and oncogenic transformation. PTPs are emerging as a promising class of sigling targets for diseases such as cancer, neurodegeneration, diabetes, and inflammation. A key challenge is to identify specific PTPs that are invovled in a disease process and develop therapeutics to modulate the PTP. FAP-1 phosphatase is thought to be important in the Fas sigling pathway. FAP-1 binds to the cytosolic tail of the Fas receptor (Apo1, CD95) and inhibits Fas-induced apoptosis. Increased FAP-1 protein levels in some tumor cell lines and tumor tissues correlates with resistance to Fas-mediated apoptosis. In general, FAP-1 expression has been found to be highest in cell lines and tissues that are relatively resistant to Fas-mediated apoptosis. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line which is consistent with an inhibitory effect of FAP-1 on Fas sigl transductions. Additiolly, FAP-1 expression correlates with Fas resistant in ovarian cancer cell lines and FAP-1 is commonly expression in ovarian cancers. Human Fas has a putative consensus tyrosine phosphorylation site (Tyrosine 275) suggesting that Fas surface expression or sigling may be regulated by phosphorylation. FAP-1 has been shown to directly bind to Fas and may dephosphorylate Fas as part of the down regulation of the apoptotic pathway. It is thought that development of therapeutics to inhibit FAP-1 may increase the ability of tumor cells with upregulated FAP-1 to undergo apoptosis. FAP-1 is a large approx. 270 kDa protein. Multiple altertively spliced FAP-1 transcript variants which encode distinct proteins have been reported, including shorter forms. Please see Application Notes section for additiol details on FAP-1 isoforms.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN13 (2451-2466) antibody

Anti-PTPN13 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit Purified Hu E, P
50 µg / €345.00
  OriGene Technologies, Inc.

PTPN13 antibody

Western Blot: PTPN13 Antibody [TA336328] - analysis of FAP-1 using this antibody. In ovarian carcinoma cell lines FAP-1 expression was detected in SK-OV-3 and OVCAR-3, but not in BG-1 or HEY. Human Jurkat T and 293 kidney cell lines were used as negative Rabbit Purified Hu C, ICC/IF, IP, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

PTPN13 antibody

Immunohistochemical analysis in paraffin-embedded human breast carcinoma tissue using PTPN13 / FAP-1 antibody (Cat.-No. AP06116PU-N). Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PTPN13 (2290-2491) antibody

Human Kidney (formalin-fixed, paraffin-embedded) stained with PTPN13 antibody AP22687PU-N at 10 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu P
0.25 ml / €470.00
  Acris Antibodies GmbH

PTPN13 antibody

PTPN13 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

PTPN13 antibody

Immunohistochemisty of PTPN13 in formalin-fixed, paraffin embedded ovarian carcinoma cores from a tissue microarray. Using PTPN13 polyclonal antibody ( Cat # PAB0256 ) at 1 : 2000. A-D, samples are from four different patients. A1-D1 are high magnification images from A-D, respectively. Hematoxylin-eosin counterstain. Rabbit Hu C, ICC/IF, IP, P, WB
50 µl / €400.00
  Abnova Taiwan Corp.

PTPN13 antibody

PTPN13 Rabbit Purified Hu E, P
50 µg / €480.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTPN13

PTPN13 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PTPN13

PTPN13 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

PTPN13 overexpression lysate

PTPN13 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

10 Item(s)

per page
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