PTPN2 / TCPTP antibody

Principal name

PTPN2 / TCPTP antibody

Alternative names for PTPN2 / TCPTP antibody

TC-PTP, T-cell protein-tyrosine phosphatase, PTPT, Tyrosine-protein phosphatase non-receptor type 2

SwissProt ID

P17706 (Human), P35233 (Rat), Q06180 (Mouse)

Gene ID

5771 (PTPN2), 19255 (Ptpn2), 117063

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Chk (Chicken), Dros (Drosophila)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of PTPN2 / TCPTP antibody

PTPN2 is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling.The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.

General readings

Shimizu,T., (2004) Exp. Hematol. 32 (11), 1057-1063

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN2 / TCPTP antibody

  PTPN2 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PTPN2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

PTPN2 - human gene knockout kit via CRISPR

PTPN2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PTPN2 - human gene knockout kit via CRISPR

PTPN2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PTPN2 - human gene knockout kit via CRISPR

PTPN2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PTPN2 - human gene knockout kit via CRISPR

PTPN2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptpn2 - mouse gene knockout kit via CRISPR

Ptpn2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ptpn2 - mouse gene knockout kit via CRISPR

Ptpn2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptpn2 - mouse gene knockout kit via CRISPR

Ptpn2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptpn2 - mouse gene knockout kit via CRISPR

Ptpn2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTPN2 / TCPTP (transcript variant 3)

  Recombinant protein of human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 3  
PTPN2 / TCPTP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PTPN2 / TCPTP (2-315, Active Enzyme)

PTPN2 / TCPTP Human Purified > 90 % as determined by Coomassie-stained SDS gel E. coli
20 µg / €500.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

PTPN2 overexpression lysate

PTPN2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, PTPN2 (mGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, PTPN2 (mGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,010.00
  OriGene Technologies, Inc.

Lenti ORF particles, PTPN2 (mGFP-tagged)-Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, PTPN2 (mGFP-tagged)-Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PTPN2 (mGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, PTPN2 (mGFP-tagged) - Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, PTPN2 (Myc-DDK tagged) - Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PTPN2 (Myc-DDK tagged) - Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €900.00
  OriGene Technologies, Inc.

Lenti ORF particles, PTPN2 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, PTPN2 (Myc-DDK-tagged)-Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, PTPN2 (Myc-DDK tagged) - Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, PTPN2 (Myc-DDK tagged) - Human protein tyrosine phosphatase, non-receptor type 2 (PTPN2), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Ptpn2 (GFP-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 2 (Ptpn2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Ptpn2 (GFP-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 2 (Ptpn2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Ptpn2 (GFP-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 2 (Ptpn2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Ptpn2 (GFP-tagged) - Mouse protein tyrosine phosphatase, non-receptor type 2 (Ptpn2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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