PTPN3 / PTPH1 antibody

Principal name

PTPN3 / PTPH1 antibody

Alternative names for PTPN3 / PTPH1 antibody

Protein-tyrosine phosphatase H1, PTP-H1, Tyrosine-protein phosphatase non-receptor type 3

SwissProt ID

P26045 (Human)

Gene ID

5774 (PTPN3)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Prim (Primate), Sh (Sheep), Rt (Rat)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of PTPN3 / PTPH1 antibody

Phosphorylation of receptors by protein kinases is a process that can be reversed by a group of enzymes called protein phosphatases. Coordinated control of kinases and phosphatases provides the cell with the capacity to rapidly switch between phosphorylated and dephosphorylated protein states in dynamic response to environmental stimuli. Activation of critical enzymes by kinase phosphorylation alone is not enough to provide adequate regulation ? it is the combination with phosphatase dephosphorylation that effectively creates on/off switches to control cellular events. Errors in control, either through kinases or their counterpart phosphatases, can lead to unchecked cell growth attributable to human cancers and developmental disorders. Potential mechanisms to control dephosphorylation include changes in the expression of protein phosphatases, their subcellular localization, phosphorylation of phosphatase catalytic and regulatory subunits and regulation by endogenous phosphatase inhibitors. Most protein phosphatases are not stringently specific for their substrates. Consequently, changes in phosphatase activity may have a broad impact on dephosphorylation and turnover of phosphoproteins that are substrates for different kinases. This may be an important point of control to connect cellular circuitry of interrelated signaling pathways, and to synchronize physiological responses.

5 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN3 / PTPH1 (Center) antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PTPH1 antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PTPN3 / PTPH1 pSer459 antibody

Western blot of mouse testes lysate showing specific immunolabeling of the ~104k PTPH1 phosphorylated at Ser 459 (Control). Phosphospecificity is shown in the second lane (lambda - phosphatase: λ -Ptase). The blot is identical to the cont rol except that the lysate was incubated in λ -Ptase (400 units/100ul lysate for 30 min, RT) before being exposed to the phospho-Ser 459 PTPH1 antibody. The immunolabeling is completely eliminated by treatment with λ -Ptase. Rabbit Ig Aff - Purified Bov, Can, Hu, Ms, Prim, Sh WB
0.1 ml / €380.00
  Acris Antibodies GmbH

PTPN3 / PTPH1 antibody

PTPN3 / PTPH1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

PTPN3 / PTPH1 antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with PTPN3 polyclonal antibody ( Cat # PAB4104 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PTPN3 / PTPH1 antibody

Immunohistochemistry-Paraffin: PTPN3 Antibody [NBP1-80868] Immunohistochemical staining of human cerebellum shows strong positivity in Purkinje cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

5 Item(s)

per page
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