PTPN5 / STEP antibody

Principal name

PTPN5 / STEP antibody

Alternative names for PTPN5 / STEP antibody

FLJ14427, STEP61, STEP46, STEP38, STEP20, Tyrosine-protein phosphatase non-receptor type 5, Neural-specific protein-tyrosine phosphatase, Striatum-enriched protein-tyrosine phosphatase

SwissProt ID

P35234 (Rat), P54829 (Human), P54830 (Mouse)

Gene ID

29644 (Ptpn5), 84867 (PTPN5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Dros (Drosophila), Ze (Zebrafish), African clawed frog, Can (Canine), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), EPair for Elisa (EPair)

Background of PTPN5 / STEP antibody

STEP (striatum-enriched phosphatase) is a neural-specific protein-tyrosine phosphatase, first isolated from the rat brain. The 537-amino acid predicted human protein as isolated from cDNA sequences is between 85 and 90% identical to the mouse and rat sequences. In rat neuronal cell cultures, glutamate-mediated activation of N-methyl-D-aspartate (NMDA) receptors leads to the rapid but transient phosphorylation of extracellular signal-related kinase-2 (ERK2). NMDA-mediated influx of calcium, activates the calcium-dependent phosphatase calcineurin and the resulting dephosphorylation and activation of STEP. STEP then inactivatea ERK2 through tyrosine dephosphorylation and blocks translocation of the kinase to the nucleus. STEP plays a significant role in regulating the ERK activation and downstream signaling in neurons.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN5 / STEP antibody

Western Blot: STEP Antibody (23E6) - Western Blot analysis of STEP protein in striatal rat protein homogenates, using anti-STEP. Mouse Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN5 / STEP antibody

WB Suggested Anti-PTPN5 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HT1080 cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rb, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTPN5 / STEP antibody

Western blot analysis of PTPN5 in Jurkat cell lysate with PTPN5 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN5 / STEP (N-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with STEP antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PTPN5 / STEP antibody

PTPN5 / STEP Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

PTPN5 / STEP antibody

Western Blot analysis of PTPN5 expression in transfected 293T cell line (H00084867-T01) by PTPN5 MaxPab polyclonal antibody.

Lane 1: PTPN5 transfected lysate(62.15 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PTPN5 / STEP antibody

PTPN5 MaxPab rabbit polyclonal antibody. Western Blot analysis of PTPN5 expression in mouse lung. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PTPN5 / STEP antibody

PTPN5 / STEP Mouse IgG1 2H5 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

PTPN5 / STEP antibody

Western blot analysis of Ptpn5 in striatal rat protein homogenates using Ptpn5 monoclonal antibody, clone 23E5 ( Cat # MAB2403 ) . Mouse 23E5 Hu, Ms, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

PTPN5 / STEP antibody

Immunoblot analysis of IMR-32 cell lysate. Mouse T41 Hu, Ms, Rt WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

PTPN5 / STEP antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with PTPN5 polyclonal antibody ( Cat # PAB4108 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

PTPN5 / STEP antibody

Human HT1080; WB Suggested Anti-PTPN5 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: HT1080 cell lysate; PTPN5 antibody - middle region (ARP44901_P050) in Human HT1080 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Chk, Dros, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

PTPN5 / STEP antibody

PTPN5 / STEP Mouse 23E5 Ascites Hu, Ms, Rt C, ICC/IF, IP, P, WB
25 µl / €200.00
  Novus Biologicals Inc.

PTPN5 / STEP antibody

PTPN5 / STEP Rabbit IgG Hu P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTPN5 / STEP (transcript variant 1)

PTPN5 / STEP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PTPN5 / STEP (transcript variant 2)

PTPN5 / STEP Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

PTPN5 / STEP

PTPN5 / STEP Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

PTPN5 / STEP

PTPN5 / STEP Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

PTPN5 / STEP

PTPN5 / STEP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PTPN5 / STEP

PTPN5 / STEP Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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