PTPN6 antibody

Principal name

PTPN6 antibody

Alternative names for PTPN6 antibody

PTPN-6, HCP, PTP1C, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1, Protein-tyrosine phosphatase SHP-1, Hematopoietic cell protein-tyrosine phosphatase, Tyrosine-protein phosphatase non-receptor type 6

SwissProt ID

P29350 (Human), P29351 (Mouse), P81718 (Rat), Q9QVA8 (Mouse)

Gene ID

5777 (PTPN6), 15170 (Ptpn6), 116689

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of PTPN6 antibody

SHP (also designated short heterodimer partner and small heterodimer partner) is an orphan nuclear receptor containing the dimerization and ligandbinding domains found in other nuclear receptors but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues including fetal liver and adrenal gland, adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7 but suppressed by oxLDL and 13-HODE, which is a ligand for PPARγ. SHP interacts with nuclear receptors including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERa and ERb). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function via competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NF-κB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NF-κB. Lastly, negative feedback regulation of a hepatic bile acid transporter NTCP is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions.

General readings

Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournes B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A.
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Nat Med. 2006 May;12(5):549-56. Epub 2006 Apr 16.
PMID: 16617349

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN6 antibody

  Rabbit anti-PTPN6 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using PTPN6 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

  Goat Polyclonal Antibody against PTPN6  
TA303216 (0.2µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

  Goat Polyclonal Antibody against PTPN6 (Internal Region)  
TA303217 (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

  Mouse Anti-Human PTPN6 / SHP-1 Monoclonal Antibody  
Anti-PTPN6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200. Mouse IgG1 Purified Hu E
50 µl / €400.00
  OriGene Technologies, Inc.

PTPN6 antibody

  Anti-PTPN6 Rabbit Polyclonal Antibody  
Predicted band size: 68 kDa . Positive control: A375 and A431 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: A375 cell lysate Lane2: A431 cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 90 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

  Rabbit Polyclonal Phospho-SHP-1 (Tyr536) Antibody (Phospho-specific)  
Western blot analysis of SHP-1 phosphorylation expression in EGF treated RAW264.7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

  Rabbit Polyclonal SHP-1 Antibody  
Western blot analysis of SHP-1 expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

  Mouse Monoclonal SHP-1 Antibody  
Western blot detection of SHP-1 in Human tonsil,Daudi,Jurkat and Raji cell lysates using SHP-1 mouse mAb (1:1000 diluted).Predicted band size:67KDa.Observed band size:67KDa. Mouse IgG2a 2B7-H7-F8 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

PTPN6 Mouse IgG2b 1SH01 Purified Hu IP, P, WB
0.1 mg / €580.00
  Acris Antibodies GmbH

PTPN6 antibody

PTPN6 Mouse IgG1 PTY11 Purified Hu C, E, ICC/IF, WB
0.5 mg / €480.00
  Acris Antibodies GmbH

PTPN6 antibody

PTPN6 Mouse IgG1 PTY15 Purified Hu C, E, ICC/IF, WB
0.5 mg / €480.00
  Acris Antibodies GmbH

PTPN6 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE). Mouse IgG1 14D5 Purified Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

PTPN6 antibody

Figure 3. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-1 antibody AP02795PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

PTPN6 antibody

Figure 3. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-1 antibody AP02795PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €240.00
  Acris Antibodies GmbH

PTPN6 antibody

Immunohistochemical analysis  in paraffin-embedded human colon carcinoma tissue using PTPN6 / SHP-1 antibody (Cat.-No. AP06412PU-N). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PTPN6 pTyr536 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-1 pTyr536 Antibody AP08023PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 ml / €320.00
  Acris Antibodies GmbH

PTPN6 pTyr536 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-1 pTyr536 Antibody AP08023PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
50 µl / €240.00
  Acris Antibodies GmbH

PTPN6 pTyr564 antibody

Western blot analysis of extracts from COS7 cells treated with EGF using SHP-1 (Phospho-Tyr564) Antibody #.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu WB
0.1 ml / €340.00
  Acris Antibodies GmbH

PTPN6 pTyr564 antibody

Western blot analysis of extracts from COS7 cells treated with EGF using SHP-1 (Phospho-Tyr564) Antibody #.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu WB
50 µl / €270.00
  Acris Antibodies GmbH

PTPN6 antibody

PTPN6 Mouse IgG1 PTY6 Purified Hu C, E, ICC/IF, WB
0.5 mg / €480.00
  Acris Antibodies GmbH

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