PTPN6 antibody

Principal name

PTPN6 antibody

Alternative names for PTPN6 antibody

PTPN-6, HCP, PTP1C, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1, Protein-tyrosine phosphatase SHP-1, Hematopoietic cell protein-tyrosine phosphatase, Tyrosine-protein phosphatase non-receptor type 6

SwissProt ID

P29350 (Human), P29351 (Mouse), P81718 (Rat), Q9QVA8 (Mouse)

Gene ID

5777 (PTPN6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of PTPN6 antibody

SHP (also designated short heterodimer partner and small heterodimer partner) is an orphan nuclear receptor containing the dimerization and ligandbinding domains found in other nuclear receptors but lacking the conserved DNA binding domain. SHP is specifically expressed in liver and other tissues including fetal liver and adrenal gland, adult spleen and small intestine. In addition, SHP is highy expressed in the murine macrophage cell line RAW 264.7, but suppressed by oxLDL and 13-HODE, which is a ligand for PPARgamma. SHP interacts with nuclear receptors including thyroid receptor, retinoic acid receptors (RAR and RXR) and estrogen receptors (ERalpha and ERbeta). SHP functions as a negative regulator of these receptors by at least three mechanisms: inhibition of DNA binding via dimerization, direct antagonism of coactivator function via competition and possibly transrepression via recruitment of putative corepressors. In oxLDL-treated, resting macrophage cells, SHP acts as a transcription coactivator of NFkappaB, suggesting that SHP is a modulatory component in the regulation of the transcriptional activities of NFkappaB. Lastly, negative feedback regulation of a hepatic bile acid transporter NTCP is controlled by bile acid-activated FXR via induction of SHP to protect the hepatocyte from bile acid-mediated damage in cholestatic conditions.

General readings

Dubois MJ, Bergeron S, Kim HJ, Dombrowski L, Perreault M, Fournes B, Faure R, Olivier M, Beauchemin N, Shulman GI, Siminovitch KA, Kim JK, Marette A.
The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis.
Nat Med. 2006 May;12(5):549-56. Epub 2006 Apr 16.
PMID: 16617349

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPN6 antibody

Western blot analysis of extracts of various cell lines, using PTPN6 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

PTPN6 MaxPab rabbit polyclonal antibody. Western Blot analysis of PTPN6 expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

PTPN6 antibody

TA303216 (0.2µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
20 µg / €200.00
  Acris Antibodies GmbH

PTPN6 antibody

TA303217 (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
20 µg / €200.00
  Acris Antibodies GmbH

PTPN6 antibody

TA303216 (0.2µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

TA303217 (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

Anti-PTPN6 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200. Mouse IgG1 Purified Hu E
50 µl / €345.00
  OriGene Technologies, Inc.

PTPN6 antibody

Predicted band size: 68 kDa . Positive control: A375 and A431 cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lane1: A375 cell lysate Lane2: A431 cell lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 90 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

Predicted band size: 68kDa. Positive control: NIH/3T3 cell lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/550 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/8000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

Western blot analysis of SHP-1 expression in NIH-3T3 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

Western blot detection of SHP-1 in Human tonsil,Daudi,Jurkat and Raji cell lysates using SHP-1 mouse mAb (1:1000 diluted).Predicted band size:67KDa.Observed band size:67KDa. Mouse IgG2a 2B7-H7-F8 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPN6 antibody

PTPN6 Mouse IgG2b 1SH01 Purified Hu IP, P, WB
0.1 mg / €570.00
  Acris Antibodies GmbH

PTPN6 antibody

PTPN6 Mouse IgG1 PTY11 Purified Hu C, E, ICC/IF, WB
0.5 mg / €420.00
  Acris Antibodies GmbH

PTPN6 antibody

PTPN6 Mouse IgG1 PTY15 Purified Hu C, E, ICC/IF, WB
0.5 mg / €420.00
  Acris Antibodies GmbH

PTPN6 antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE). Mouse IgG1 14D5 Purified Hu E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

PTPN6 antibody

Figure 3. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-1 antibody AP02795PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

PTPN6 antibody

Figure 3. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-1 antibody AP02795PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µl / €230.00
  Acris Antibodies GmbH

PTPN6 antibody

Immunohistochemical analysis  in paraffin-embedded human colon carcinoma tissue using PTPN6 / SHP-1 antibody (Cat.-No. AP06412PU-N). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

PTPN6 pTyr536 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-1 pTyr536 Antibody AP08023PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 ml / €320.00
  Acris Antibodies GmbH

PTPN6 pTyr536 antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using SHP-1 pTyr536 Antibody AP08023PU. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
50 µl / €240.00
  Acris Antibodies GmbH

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