PTPRN2 antibody

Principal name

PTPRN2 antibody

Alternative names for PTPRN2 antibody

R-PTP-N2, ICAAR, IAR, IA-2beta, Phogrin, KIAA0387, Receptor-type tyrosine-protein phosphatase N2, Islet cell autoantigen-related protein

SwissProt ID

P80560 (Mouse), Q63475 (Rat), Q92932 (Human)

Gene ID

5799 (PTPRN2), 29714 (Ptprn2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP)

Background of PTPRN2 antibody

The protein encoded by the PTPRN2 gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

General readings

Bailey, S.D., et al. Diabetes Care 33(10): 2250-2253 (2010)
Rose, J.E., et al. Mol. Med. 16 (7-8): 247-253 (2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5): 800-812 (2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4): 649-656 (2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5): 628-642 (2009)

4 Item(s)

per page

CRISPR

Catalog No. Species Donor Vector  

PTPRN2 - human gene knockout kit via CRISPR

PTPRN2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

PTPRN2 - human gene knockout kit via CRISPR

PTPRN2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

PTPRN2 - human gene knockout kit via CRISPR

PTPRN2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

PTPRN2 - human gene knockout kit via CRISPR

PTPRN2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

4 Item(s)

per page
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