PTPRN2 antibody

Principal name

PTPRN2 antibody

Alternative names for PTPRN2 antibody

R-PTP-N2, ICAAR, IAR, IA-2beta, Phogrin, KIAA0387, Receptor-type tyrosine-protein phosphatase N2, Islet cell autoantigen-related protein

SwissProt ID

P80560 (Mouse), Q63475 (Rat), Q92932 (Human)

Gene ID

5799 (PTPRN2), 29714 (Ptprn2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP)

Background of PTPRN2 antibody

The protein encoded by the PTPRN2 gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

General readings

Bailey, S.D., et al. Diabetes Care 33(10): 2250-2253 (2010)
Rose, J.E., et al. Mol. Med. 16 (7-8): 247-253 (2010)
Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5): 800-812 (2010)
Yoshida, T., et al. Int. J. Mol. Med. 25(4): 649-656 (2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5): 628-642 (2009)

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTPRN2 (transcript variant 2)

  Recombinant protein of human protein tyrosine phosphatase, receptor type, N polypeptide 2 (PTPRN2), transcript variant 2  
PTPRN2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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