PTPRT antibody

Principal name

PTPRT antibody

Alternative names for PTPRT antibody

PTP rho, RPTP-rho, R-PTP-T, KIAA0283, Receptor-type tyrosine-protein phosphatase T, Receptor-type tyrosine-protein phosphatase rho, KIAA0283

SwissProt ID

O14522 (Human), Q99M80 (Mouse), Q9NTL1 (Human)

Gene ID

11122 (PTPRT)

Available reactivities

Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of PTPRT antibody

The protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as I-kappa B-alpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.

General readings

Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE.
Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science. 2004 May 21;304(5674):1164-6.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTPRT antibody

TA302963 staining (0.3µg/ml) of Human Brain lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTPRT antibody

Predicted cell location: Cytoplasm. Positive control: Human ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using PTPRT antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTPRT antibody

PTPRT Mouse IgG2a 3D7 Purified Hu, Por, Rt F, ICC/IF, IP, WB
0.1 mg / €550.00
  Acris Antibodies GmbH

PTPRT antibody

Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PTPRT antibody

PTPRT Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

PTPRT antibody

Immunoblot analysis of cell lysates.
Lane 1 : Bosc23 cell lysate.
Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau ( 1-441 a. a.).
Lane 3 : Bosc23 cell lysate transfected with Myc/His/PTPRT.
Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1. Mouse AFT20 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

PTPRT antibody

Immunoblot analysis of cell lysates.
Lane 1 : Bosc23 cell lysate.
Lane 2 : Bosc23 cell lysate transfected with Myc/His/Tau ( 1-441 a. a. ).
Lane 3 : Bosc23 cell lysate transfected with Myc/His/PTPRT rho (887-1169 a. a. ).
Lane 4 : Bosc23 cell lysate transfected with GFP-Ubiquitin+1. Mouse T20-AF3C7 Hu IP, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

PTPRT antibody

PTPRT polyclonal antibody ( Cat # PAB6685 ) staining ( 0.3 µg/ml ) of human brain lysate ( RIPA buffer, 35 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

PTPRT antibody

NB 100-1459 staining (1.5µg/ml) of Human Brain lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

PTPRT antibody

Immunohistochemistry-Paraffin: PTPRT Antibody [NBP1-81524] Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

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