PTRH2 / BIT1 antibody

Principal name

PTRH2 / BIT1 antibody

Alternative names for PTRH2 / BIT1 antibody

PTH2, CGI-147, Peptidyl-tRNA hydrolase 2 mitochondrial

SwissProt ID

Q3ZBL5 (Bovin), Q8R2Y8 (Mouse), Q9Y3E5 (Human)

Gene ID

51651 (PTRH2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of PTRH2 / BIT1 antibody

Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment (1). Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process (2). Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination (3). It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE (2). Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin (2).

General readings

Jan Y., et al. (2004) Cell. 116(5):751-62.
De Pereda JM., et al. (2004) J Biol Chem. 279(9):8111-5.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTRH2 / BIT1 (N-term) antibody

Western blot analysis of Bit1 in A-20 cell lysate with Bit1 antibody at (A) 1, (B) 2, and (C) 4 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTRH2 / BIT1 (Center) antibody

Western blot analysis of Bit1 in Daudi cell lysate with Bit1 antibody at (A) 1, (B) 2, and (C) 4 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTRH2 / BIT1 antibody

WB Suggested Anti-PTRH2 Antibody Titration: 1.25 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

PTRH2 / BIT1 antibody

Western Blot: PTRH2 Antibody [TA336319] - Western blot analysis of Bit1 in Daudi cell lysate with Bit1 antibody using TA336319 at (A) 1, (B) 2, and © 4 ug/ml. Rabbit Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTRH2 / BIT1 (N-term) antibody

Testis: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

PTRH2 / BIT1 Control Peptide

PTRH2 / BIT1
50 µg / €160.00
  Acris Antibodies GmbH

PTRH2 / BIT1 Control Peptide

PTRH2 / BIT1
50 µg / €160.00
  Acris Antibodies GmbH

PTRH2 / BIT1 antibody

Western Blot analysis of PTRH2 expression in transfected 293T cell line (H00051651-T01) by PTRH2 MaxPab polyclonal antibody.

Lane 1: BIT1 transfected lysate(19.8 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PTRH2 / BIT1 antibody

BIT1 MaxPab polyclonal antibody. Western Blot analysis of BIT1 expression in human placenta. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

PTRH2 / BIT1 antibody

PTRH2 / BIT1 Rabbit Hu E
0.4 ml / €390.00
  Abnova Taiwan Corp.

PTRH2 / BIT1 antibody

Immunocytochemistry of PTRH2 in NIH/3T3 cells with PTRH2 polyclonal antibody ( Cat # PAB13163 ) at 2 µg/ml. Rabbit Hu, Ms, Rt ICC/IF, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

PTRH2 / BIT1 antibody

Immunohistochemistry of PTRH2 in human small intestine tissue with PTRH2 polyclonal antibody ( Cat # PAB13164 ) at 10 µg/ml. Rabbit Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

PTRH2 / BIT1 antibody

Human Jurkat; WB Suggested Anti-PTRH2 Antibody Titration: 1.25ug/ml. Positive Control: Jurkat cell lysate; PTRH2 antibody - C-terminal region (ARP44695_T100) in Human Jurkat cells using Western Blot Rabbit Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 mg / €310.00
  AVIVA Systems Biology

PTRH2 / BIT1 antibody

PTRH2 / BIT1 Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

PTRH2 / BIT1 antibody

Immunohistochemistry-Paraffin: PTRH2 Antibody [NBP1-76644] - Bit1 in human small intestine tissue with Bit1 antibody at 10 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

PTRH2 / BIT1 antibody

Immunohistochemistry-Paraffin: PTRH2 Antibody [NBP1-88595] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity, with a granular pattern, in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTRH2 / BIT1 (64-179, His-tag)

PTRH2 / BIT1 Human Purified > 95 % E. coli
0.5 mg / €1,000.00
  Acris Antibodies GmbH

PTRH2 / BIT1 (64-179, His-tag)

PTRH2 / BIT1 Human Purified > 95 % E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

PTRH2 / BIT1

PTRH2 / BIT1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

PTRH2 / BIT1

PTRH2 / BIT1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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