PTRH2 / BIT1 antibody

Principal name

PTRH2 / BIT1 antibody

Alternative names for PTRH2 / BIT1 antibody

PTH2, CGI-147, Peptidyl-tRNA hydrolase 2 mitochondrial

SwissProt ID

Q3ZBL5 (Bovin), Q8R2Y8 (Mouse), Q9Y3E5 (Human)

Gene ID

51651 (PTRH2), 217057 (Ptrh2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of PTRH2 / BIT1 antibody

Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment (1). Bit1 (Bcl-2 inhibitor of transcription 1) was recently identified as being involved in this process (2). Bit1 is a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. Both AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination (3). It has been suggested that Bit1-AES complexes turn off a survival-promoting gene transcription program controlled by TLE (2). Interestingly, apoptosis of cells transfected with Bit1 and AES could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin (2).

General readings

Jan Y., et al. (2004) Cell. 116(5):751-62.
De Pereda JM., et al. (2004) J Biol Chem. 279(9):8111-5.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTRH2 / BIT1 antibody

  Rabbit Polyclonal Anti-PTRH2 Antibody  
WB Suggested Anti-PTRH2 Antibody Titration: 1.25 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Por, Rb WB
0.1 mg / €360.00
  OriGene Technologies, Inc.

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