PTX3 antibody

Principal name

PTX3 antibody

Alternative names for PTX3 antibody

TNFAIP5, TSG14, TSG-14, Pentraxin-related protein PTX3, Pentaxin-related protein PTX3, Tumor necrosis factor alpha-induced protein 5, TNF alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein

SwissProt ID

P26022 (Human), P48759 (Mouse), Q0VCG9 (Bovin)

Gene ID

5806 (PTX3), 19288 (Ptx3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Can (Canine)

Available hosts

Mouse, Rabbit, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C), Functional assay (FN), Immunohistochemistry (IHC)

Background of PTX3 antibody

PTX3 is an acute-phase glycoprotein of ~45 kDa with glycosylation accounting for about 10% of its molecular weight. PTX3 has a complex oligomeric structure with protomers linked to each other by disulfide bonds. PTX3 expression is triggered by inflammatory cytokines, resulting in higher levels of circulating PTX3. Several cell types have been reported to produce PTX3, namely macrophages, endothelial cells, neutrophils and synoviocytes. PTX3 is involved in host defense against pathogen infection, in the regulation of the scavenger activity of macrophages and dendritic cells, and in modulation of complement activity by binding to C1q. Furthermore, PTX3 has been implicated in matrix deposition of cumulus cells. Moreover, PTX3 interacts with other biologically active molecules, causing their functional blockade. This has been demonstrated for fibroblast growth factor-2 (FGF-2), for which PTX3 acts as an inhibitor, leading to inhibition of angiogenesis. PTX3, like other pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP), binds apoptotic cells and debris. PTX3 is useful as an early indicator of myocyte irreversible injury in ischemic cardiomyopathy. PTX3 is not only involved in inflammatory vessel diseases related to atherosclerosis, but also in pre-eclampsia and systemic small vessel ANCA-associated vasulitis, in which neutrophils are key players. The relationship between tissue damage and pentraxin generation is stringent in acute injuries. PTX3 tunes self-non-self discrimination and tissue repair due to the recognition of diverse ligands by PTX3 and through regulation of effector pathways.

General readings

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253 (2010).
Yilmaz, M.I., et al. Clin J Am Soc Nephrol 5(7):1174-1181 (2010).
Haverkamp, M.H., et al. Int. J. Pediatr. Otorhinolaryngol. 74(7):752-754 (2010).
Hollan, I., et al. Arthritis Care Res (Hoboken) 62(3):378-385 (2010).
Sciacca, P., et al. Front Biosci (Elite Ed) 2, 805-809 (2010).

Items 1 to 20 of 24 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

PTX3 antibody

  Rabbit polyclonal anti-PTX3 antibody  
Western blot analysis of extracts from 293 cells, using PTX3 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTX3 antibody

  Rabbit polyclonal Anti-PTX3 Antibody  
WB Suggested Anti-PTX3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTX3 antibody

  Rabbit polyclonal Anti-PTX3 Antibody  
WB Suggested Anti-PTX3 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Bov, Hu, Ms, Por, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

PTX3 antibody

  Rabbit Polyclonal Anti-PTX3 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane: Human normal lung tissue, Primary antibody: (PTX3 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

PTX3 antibody

PTX3 Rat IgG2a MNB4 Purified Hu C, E, F, ICC/IF, IP, P, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

PTX3 antibody

PTX3 Rat IgG2b MNB1 Purified Hu C, E, FN, IP, P, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

PTX3 (Center) antibody

Western blot analysis of PTX3 Antibody (Center) Cat.-No AP53517PU-N in A549 cell line lysates (35ug/lane). This demonstrates the PTX3 antibody detected the PTX3 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

PTX3 antibody

Immunofluorescence analysis of HuvEc cells, using PTX3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

PTX3 antibody

Immunofluorescence analysis of HuvEc cells, using PTX3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Ptx3 - mouse gene knockout kit via CRISPR

Ptx3 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Ptx3 - mouse gene knockout kit via CRISPR

Ptx3 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptx3 - mouse gene knockout kit via CRISPR

Ptx3 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Ptx3 - mouse gene knockout kit via CRISPR

Ptx3 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

PTX3

  Recombinant protein of human pentraxin-related gene, rapidly induced by IL-1 beta (PTX3)  
PTX3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

PTX3 (18-381, His-tag)

PTX3 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €1,000.00
  Acris Antibodies GmbH

PTX3 (18-381, His-tag)

PTX3 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

ELISA Kits

Catalog No.    

Human PTX3/Pentraxin 3 ELISA Kit

Human PTX3/Pentraxin 3 ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

Mouse PTX3/Pentraxin 3 ELISA Kit

Mouse PTX3/Pentraxin 3 ELISA Kit  
1 kit / €389.00
  OriGene Technologies, Inc.

OmniKine™ Human Pentraxin-3 ELISA Kit

OmniKine™ Human Pentraxin-3 ELISA Kit  
96 Tests / €440.00
  Assay Biotech

Lysates

Catalog No.    

PTX3 overexpression lysate

PTX3 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Items 1 to 20 of 24 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn