RAGE / AGER antibody

Principal name

RAGE / AGER antibody

Alternative names for RAGE / AGER antibody

Advanced glycosylation end product-specific receptor, Receptor for advanced glycosylation end products

SwissProt ID

Q15109 (Human), Q28173 (Bovin), Q62151 (Mouse), Q63495 (Rat)

Gene ID

177 (AGER), 8045 (RASSF7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chimp (Chimpanzee), Mky (Monkey), Por (Porcine), Rb (Rabbit), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), ELISA (detection) (E(detection)), Flow Cytometry (F), Functional assay (FN), Neutralisation (NEUT)

Background of RAGE / AGER antibody

Advanced glycosylation end product-specific receptor (AGER; RAGE) is a member of the immunoglobulin superfamily of cell surface molecules that binds molecules that have been irreversibly modified by non-enzymatic glycation and oxidation, and are know as advanced glycation end products (AGEs). It is expressed by endothelium, mononuclear phagocytes, neurons and smooth muscle cells. Whereas RAGE is present at high levels during development, especially in the central nervous system, its levels decline during maturity.The increased expression of RAGE is associated with several pathological states, such as diabetic vasculopathy, neuropathy, retinopathy and other disorders, including Alzheimer's disease and immune/inflammatory reactions of the vessel walls. In diabetic tissues, the production of RAGE is due to the overproduction of AGEs that eventually overwhelm the protective properties of RAGE. This results in oxidative stress and endothelial cell dysfunction that leads to vascular disease in diabetics. In the brain, RAGE also binds amyloid beta (Ab). Because Ab is overproduced in neurons and vessels in the brains of Alzheimer disease, this leads to the hyperstimulation of RAGE. The RAGE-Ab interaction is thought to result in oxidative stress leading to neuronal degeneration.

General readings

Takahashi,K., (2006) Thromb. Haemost. 95 (2), 320-328

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RAGE / AGER antibody

Western blot analysis of Human kidney and mouse brain tissue using TA321286(AGER Antibody) at dilution 1/750 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RAGE / AGER antibody

AGER Antibody (W363) (Cat. #TA324716) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the AGER antibody detected the AGER protein (arrow). Rabbit IgG Purified Hu P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

RAGE / AGER antibody

Western blot analysis of AGER Antibody (N-term) (cat. #TA324792) in mouse lung tissue lysates (35ug/lane). AGER (arrow) was detected using the purified Pab. Rabbit IgG Purified Hu, Ms F, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

RAGE / AGER antibody

Western blot analysis of extracts of mouse lung cell line, using AGER antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RAGE / AGER antibody

WB Suggested Anti-AGER Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

RAGE / AGER (N-term) antibody

RAGE / AGER Goat Serum Hu P
0.2 ml / €330.00
  Acris Antibodies GmbH

RAGE / AGER (42-59) antibody

RAGE / AGER Goat Serum Bov, Hu, Ms, Rt E, P, WB
0.1 ml / €540.00
  Acris Antibodies GmbH

RAGE / AGER (N-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Purified Hu P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

RAGE / AGER antibody

Immunohistochemical analysis of Paraffin-Embedded Rat Tissue Sections (Lung) using RAGE antibody. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.2 ml / €340.00
  Acris Antibodies GmbH

RAGE / AGER (Extracell. Dom.) antibody

RAGE / AGER Rat IgG2 2B65 Purified Ms C, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

RAGE / AGER (42-59) antibody

RAGE / AGER Goat Serum Bov, Can, Chimp, Hu, Mky, Ms, Por, Rb, Rt E, FN, P, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

RAGE / AGER antibody

Western Blot analysis of AGER expression in transfected 293T cell line (H00000177-T01) by AGER MaxPab polyclonal antibody.

Lane 1: AGER transfected lysate(44.44 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

RAGE / AGER antibody

AGER MaxPab rabbit polyclonal antibody. Western Blot analysis of AGER expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

RAGE / AGER antibody

Western Blot analysis of AGER expression in transfected 293T cell line by AGER monoclonal antibody (M02), clone 1C1.

Lane 1: AGER transfected lysate(42.8 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1C1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

RAGE / AGER antibody

RAGE / AGER Mouse IgG2a 1C1 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

RAGE / AGER antibody

RAGE / AGER Mouse IgG2a 1C1 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

RAGE / AGER antibody

Western Blot analysis of AGER expression in transfected 293T cell line by AGER monoclonal antibody (M02J), clone 1C1.

Lane 1: AGER transfected lysate(42.8 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1C1 Purified Hu E, WB
50 µg / €370.00
  Abnova Taiwan Corp.

RAGE / AGER antibody

Western Blot analysis of AGER expression in transfected 293T cell line by AGER monoclonal antibody (M05), clone 1D1.

Lane 1: AGER transfected lysate(42.8 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1D1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

RAGE / AGER antibody

Immunocytochemistry analysis of CHO cells overexpressing human AGER, using AGER monoclonal antibody, clone 1C5 ( Cat # MAB1724 ) . Mouse IgG1 1C5 Hu E, F, ICC/IF, WB
50 µg / €740.00
  Abnova Taiwan Corp.

RAGE / AGER antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with AGER polyclonal antibody ( Cat # PAB4295 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated . BC = breast carcinoma . Rabbit Hu E, P
0.4 ml / €390.00
  Abnova Taiwan Corp.

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