RANBP2 antibody

Principal name

RANBP2 antibody

Alternative names for RANBP2 antibody

Ran-binding protein 2, Nucleoporin Nup358, E3 SUMO-protein ligase RanBP2, Nuclear pore complex protein Nup358

SwissProt ID

P48820 (Bovin), P49792 (Human), Q9ERU9 (Mouse)

Gene ID

5903 (RANBP2)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of RANBP2 antibody

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq]

General readings

General / background references:Fauser S et al. Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene. Mamm Genome 12:406-15 (2001). PubMed PMID: 11353387
Ferreira PA Characterization of RanBP2-associated molecular components in neuroretina. Methods Enzymol 315:455-68 (2000). PubMed PMID: 10736720
Chook YM et al. Pictures in cell biology. Structures of nuclear-transport components. Trends Cell Biol 9:310-1 (1999). PubMed PMID: 10490335

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