RAP1A antibody

Principal name

RAP1A antibody

Alternative names for RAP1A antibody

RAP-1A, C21KG, KREV1, KREV-1, Ras-related protein Rap-1A, GTP-binding protein smg p21A, Ras-related protein Krev-1

SwissProt ID

P62833 (Bovin), P62834 (Human), P62835 (Mouse), P62836 (Rat)

Gene ID

5906 (RAP1A), 109905 (Rap1a), 295347

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Gt (Goat), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)

Background of RAP1A antibody

Rap1A is a 21 kDa small GTP-binding protein that antagonizes the Ras transforming activity through tight binding to Ras-GAP. It interferes with Ras-dependent Raf1 activation by inhibiting binding of Ras to the cysteine-rich region of Raf1. This protein is localized in the endoplasmic reticulum, late endosomes, and lysosomes, indicating its potential role in the regulation of
intracellular protein degradation. Rap1a contains a C-terminal CLLL motif for post-translational geranylgeranylation and a single site for phosphorylation by protein kinase A. Ras proteins provide a crucial link in the intracellular signalling cascades. Ras proteins are members of the small G protein family. These proteins are characterized by a molecular weight between 20 and 30 kDa, the ability to bind GTP or GDP and a low intrinsic GTPase activity. These proteins relay signals from the plasma membrane activated by receptor tyrosine kinases to the nucleus via a network of serine/threonine kinases. Ras proteins belong to a family of approximately 40 mammalian and 60 non-mammalian proteins. Ras proteins were first discovered as the hyperactive products of mutant Ras genes which promote cancer by disrupting the normal controls on cell proliferation and differentiation; about 30% of human cancers have mutations in a Ras gene.

General readings

Mol Biol Cell. 2009 Apr;20(7):1916-25.
J Cell Sci. 2009 Aug 15;122(Pt 16):2996-3004.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RAP1A antibody

Western blot analysis using RAP1A antibody Cat.-No AM06750PU-N against human RAP1A (AA: 28-180) recombinant protein. (Expected MW is 43.2 kDa) Mouse IgG1 5F8 Purified Hu E, F, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

RAP1A antibody

Western blot analysis using RAP1A antibody Cat.-No AM06751PU-N against Human RAP1A (AA: 28-180) recombinant protein (Expected MW is 21 kDa). Mouse IgG1 5F8G2 Purified Hu E, F, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

RAP1A antibody

  Rabbit polyclonal antibody to RAP1A (RAP1A, member of RAS oncogene family)  
Sample (30 ug of whole cell lysate). A: Molt-4 . 12% SDS PAGE. RAP1A antibody. TA308128 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RAP1A antibody

  Anti-RAP1A Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid and liver cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using RAP1A antibody at dilution 1/35, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

RAP1A antibody

  Anti-RAP1A Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human gastric and lung cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human gastric cancer tissue using RAP1A antibody at dilution 1/45, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

RAP1A antibody

  Rabbit Polyclonal Anti-Rap1a Antibody  
RAP1A Rabbit IgG Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

RAP1A antibody

  Rabbit Polyclonal Anti-RAP1A Antibody  
Host: Rabbit; Target Name: Rap1a; Sample Tissue: Mouse Testis lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

RAP1A (C-term) antibody

Western blot analysis of RAP1A Antibody (C-term) Cat.-No AP53578PU-N in mouse spleen tissue lysates (35ug/lane). This demonstrates the RAP1A antibody detected the RAP1A protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Rap1a - mouse gene knockout kit via CRISPR

Rap1a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Rap1a - mouse gene knockout kit via CRISPR

Rap1a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rap1a - mouse gene knockout kit via CRISPR

Rap1a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rap1a - mouse gene knockout kit via CRISPR

Rap1a - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RAP1A (transcript variant 2)

  Recombinant protein of human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2  
RAP1A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

RAP1A

RAP1A Human Purified
25 µg / €410.00
  Acris Antibodies GmbH

RAP1A (1-181, His-tag)

RAP1A Human Purified > 85 % by SDS - PAGE E. coli
0.25 mg / €1,000.00
  Acris Antibodies GmbH

RAP1A (1-181, His-tag)

RAP1A Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €370.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, RAP1A (mGFP-tagged) - Human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, RAP1A (mGFP-tagged) - Human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, RAP1A (mGFP-tagged) - Human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, RAP1A (mGFP-tagged) - Human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, RAP1A (Myc-DDK tagged) - Human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, RAP1A (Myc-DDK tagged) - Human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, RAP1A (Myc-DDK tagged) - Human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, RAP1A (Myc-DDK tagged) - Human RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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