RAP2B antibody

Principal name

RAP2B antibody

Alternative names for RAP2B antibody

Rap-2b, Ras-related protein Rap-2b

SwissProt ID

P61225 (Human), P61226 (Mouse), P61227 (Rat)

Gene ID

5912 (RAP2B), 74012 (Rap2b), 170923

Available reactivities

Hu (Human)

Available hosts

Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of RAP2B antibody

Rap2B is a 21 kDa small GTP-binding protein that that exhibits 46% identity with Ras proteins and is similarly post-translationally modified by farnesyl and palmitate groups. It colocalizes with several markers of the Golgi complex, thus indicating that its site of function was distinct from that of Rap1A. In contrast to Rap1A, Rap2B protein does not interfere with Ras-induced transformation suggesting that the activity of Rap proteins goes beyond the regulation of Ras protein function.
Ras proteins provide a crucial link in the intracellular signalling cascades. Ras proteins are members of the small G protein family. These proteins are characterized by a molecular weight between 20 and 30 kDa, the ability to bind GTP or GDP and a low intrinsic GTPase activity. These proteins relay signals from the plasma membrane activated by receptor tyrosine kinases to the nucleus via a network of serine/threonine kinases. Ras proteins belong to a family of approximately 40 mammalian and 60 non-mammalian proteins. Ras proteins were first discovered as the hyperactive products of mutant Ras genes which promote cancer by disrupting the normal controls on cell proliferation and differentiation; about 30% of human cancers have mutations in a Ras gene.

General readings

Evellin. S., et al. (2002) J Biol Chem 277: 16805-16813. 
Stope. M.B., et al. (2004) Mol Cell Biol 24: 4664-4676. 
Greco. F., et al. (2006) Biochim Biophys Acta 1763: 330-335.

9 Item(s)

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Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RAP2B

  Recombinant protein of human RAP2B, member of RAS oncogene family (RAP2B)  
RAP2B Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

RAP2B

RAP2B Human Purified
25 µg / €410.00
  OriGene Technologies GmbH

RAP2B (1-183, His-tag)

RAP2B Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €730.00
  OriGene Technologies GmbH

RAP2B (1-183, His-tag)

RAP2B Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  OriGene Technologies GmbH

Lysates

Catalog No.    

RAP2B overexpression lysate

RAP2B overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Rap2b (GFP-tagged) - Mouse RAP2B, member of RAS oncogene family (Rap2b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rap2b (GFP-tagged) - Mouse RAP2B, member of RAS oncogene family (Rap2b), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rap2b (Myc-DDK-tagged) - Mouse RAP2B, member of RAS oncogene family (Rap2b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rap2b (Myc-DDK-tagged) - Mouse RAP2B, member of RAS oncogene family (Rap2b), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Rap2b (GFP-tagged ORF) - Rat RAP2B, member of RAS oncogene family (Rap2b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rap2b (GFP-tagged ORF) - Rat RAP2B, member of RAS oncogene family (Rap2b), 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rap2b (Myc-DDK-tagged ORF) - Rat RAP2B, member of RAS oncogene family (Rap2b), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rap2b (Myc-DDK-tagged ORF) - Rat RAP2B, member of RAS oncogene family (Rap2b), 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

9 Item(s)

per page
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