RASD2 / TEM2 antibody

Principal name

RASD2 / TEM2 antibody

Alternative names for RASD2 / TEM2 antibody

GTP-binding protein Rhes, Ras homolog enriched in striatum, Tumor endothelial marker 2

SwissProt ID

P63032 (Mouse), P63033 (Rat), Q96D21 (Human)

Gene ID

23551 (RASD2), 75141 (Rasd2), 171099

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Can (Canine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of RASD2 / TEM2 antibody

Rhes, Ras homolog enriched in striatum, belongs to the RASD subfamily of the Ras-related GTP-binding protein superfamily. By responding to extracellular signals, these proteins regulate intracellular signaling pathways, thereby controlling essential cellular functions such as cell growth, gene transcription, and cytoskeleton organization and also pathways involved in synaptic plasticity, learning and memory (1). Rhes, located on mouse chromosome 8, is a product of thyroid hormone-regulated gene during brain development and it regulates signal transduction from G protein-coupled receptors (2). It is implicated in cAMP/PKA signaling pathway- Rhes has been shown to inhibit the cAMP/PKA pathway by thyroid-stimulating hormone (3). Furthermore, Rhes modulates dopamine signaling in the striatum. It is essential for correct dopamine-mediated GTP binding (4).
Studies investigating the role of Rhes have shown that mice that are deficient in this protein were smaller than the wild type mice (1). These mice also showed behavioral abnormalities such as gender-dependent increase in anxiety levels and lack of clear motor coordination. Such studies also showed that absence of Rhes modulated cAMP/PKA signaling in projection neurons by increasing golf protein levels (2). Rhes is expressed in brain areas that receive dopaminergic input, such as striatum. Therefore, its mRNA expression is controlled by dopamine and its expression is reduced under conditions of dopamine supersensitivity (5). Rhes has also been shown to bind huntingtin and mutant huntingtin protein (6). Expansion of huntingtin is usually seen in patients with Huntington’s disease. Rhes is approximately a 70kDa protein (6), higher than the predicted MW of 38kDa (317 amino acids).

General readings

Hill, C., et al. Cell. Physiol. Biochem. 23 (1-3), 1-8 (2009) : Liu, Y.L., et al. Biol. Psychiatry 64(9):789-796(2008) Thapliyal, A., et al. Am. J. Physiol., Cell Physiol. 295 (5), C1417-C1426 (2008) : Agretti, P., et al. J. Endocrinol. Invest. 30(4):279-284(2007) Taylor, J.P., et al. Biochem. Biophys. Res. Commun. 349(2):809-815(2006)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RASD2 / TEM2 antibody

  RASD2 mouse monoclonal antibody, clone OTI1G1 (formerly 1G1)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-RASD2 mouse monoclonal antibody. (TA501978) Mouse IgG2a OTI1G1 Purified Can, Hu F, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

RASD2 / TEM2 antibody

  RASD2 mouse monoclonal antibody, clone OTI1A12 (formerly 1A12)  
Anti-RASD2 mouse monoclonal antibody (TA502070) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RASD2(RC201454). Mouse IgG2a OTI1A12 Purified Hu, Rt F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

RASD2 / TEM2 antibody

  RASD2 mouse monoclonal antibody, clone OTI1F7 (formerly 1F7)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-RASD2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502072) Mouse IgG1 OTI1F7 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

RASD2 / TEM2 antibody

  RASD2 mouse monoclonal antibody, clone OTI1D11 (formerly 1D11)  
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-RASD2 monoclonal antibody. Mouse IgG2a OTI1D11 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

RASD2 / TEM2 antibody

  RASD2 mouse monoclonal antibody, clone OTI1H10 (formerly 1H10)  
Anti-RASD2 mouse monoclonal antibody (TA502074) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RASD2(RC201454). Mouse IgG2a OTI1H10 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

RASD2 / TEM2 (N-term) antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with RASD2 antibody AP22664PU-N at 2.5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

RASD2 / TEM2 (C-term) antibody

  Rabbit Polyclonal TEM2 Antibody  
Western blot analysis of TEM2 in human colon tissue lysate with TEM2 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RASD2 / TEM2 (N-term) antibody

  Rabbit Polyclonal TEM2 Antibody  
Western blot analysis of TEM2 in rat colon tissue lysate with TEM2 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RASD2 / TEM2 antibody

  Rabbit polyclonal RASD2 antibody  
Western blot analysis of extracts from Jurkat cells, using RASD2 antibody. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RASD2 / TEM2 antibody

  Rabbit Polyclonal Anti-RASD2 Antibody  
Gel: 12%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Mouse kidney tissue and hela cell, Primary antibody: (RASD2 Antibody) at dilution 1/400 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RASD2 / TEM2 antibody

  RASD2 mouse monoclonal antibody, clone OTI1G8 (formerly 1G8)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RASD2 (RC201454, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RASD2. Mouse IgG1 OTI1G8 Purified Hu F, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

RASD2 / TEM2 antibody

  RASD2 mouse monoclonal antibody, clone OTI2G8 (formerly 2G8)  
Anti-RASD2 mouse monoclonal antibody (TA502092) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RASD2(RC201454). Mouse IgG2a OTI2G8 Purified Hu F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

RASD2 / TEM2 (Center) antibody

RASD2 Antibody (Center) (Cat. #AP53587PU-N) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the RASD2 antibody detected the RASD2 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

RASD2 - human gene knockout kit via CRISPR

RASD2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

RASD2 - human gene knockout kit via CRISPR

RASD2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RASD2 - human gene knockout kit via CRISPR

RASD2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RASD2 - human gene knockout kit via CRISPR

RASD2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rasd2 - mouse gene knockout kit via CRISPR

Rasd2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Rasd2 - mouse gene knockout kit via CRISPR

Rasd2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rasd2 - mouse gene knockout kit via CRISPR

Rasd2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Items 1 to 20 of 31 total

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