RBX1 / RNF75 antibody

Principal name

RBX1 / RNF75 antibody

Alternative names for RBX1 / RNF75 antibody

Protein ZYP, ROC1, E3 ubiquitin-protein ligase RBX1, RING finger protein 75, RING-box protein 1, Regulator of cullins 1

SwissProt ID

O13959 (Schpo), P62877 (Human), P62878 (Mouse), Q08273 (Yeast), Q23457 (Caeel)

Gene ID

9978 (RBX1), 56438 (Rbx1)

Available reactivities

Ce (C. elegans), Hu (Human), Ms (Mouse), Ze (Zebrafish), Bov (Bovine), Can (Canine), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of RBX1 / RNF75 antibody

ROC1 also known as RING-box protein 1, Rbx1, Regulator of cullins 1, RING finger protein 75, and ZYP protein, is a component of the SCF (SKP1-CUL1-F-box protein) and the CBC(VHL) (CUL2-elonging BC-VHL) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. ROC1 appears to recruit the E2 ubiquitination enzyme through the RING-type zinc finger in a manner similar to CDC34, and brings it into close proximity to the substrate. The RING-type zinc finger domain is essential for ubiquitin ligase activity. ROC1 probably also stimulates CDC34 autoubiquitination and promotes the neddylation of CUL1 and probably CUL2. ROC1 has a cytoplasmic and nuclear localization and is widely expressed in most tissues.

General readings

Zheng, N., et al., (2002) Nature 416 (6882), 703-709.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RBX1 / RNF75 antibody

Human tonsil stained with Anti-ROC1 Rabbit Purified Hu, Ms P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

RBX1 / RNF75 antibody

Human tonsil stained with Anti-ROC1 Rabbit Purified Hu, Ms P, WB
1 ml / €450.00
  Acris Antibodies GmbH

RBX1 / RNF75 antibody

Human tonsil stained with Anti-ROC1 Rabbit Purified Hu, Ms P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

RBX1 / RNF75 antibody

Human Tonsil stained with anti-ROC1 antibody. Rabbit Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

RBX1 / RNF75 antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Liver. Rabbit Hu E, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

RBX1 / RNF75 (C-term) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms P
0.25 ml / €470.00
  Acris Antibodies GmbH

RBX1 / RNF75 (C-term) antibody

Figure 1. Conjugation pathways for ubiquitin and
ubiquitin-like modifiers (UBLs). Most modifiers mature by
proteolytic processing from inactive precursors (a; amino acid).
Arrowheads point to the cleavage sites. Ubiquitin is expressed either
as polyubiquitin or as a fusion with ribosomal proteins. Conjugation
requires activating (E1) and conjugating (E2) enzymes that form
thiolesters (S) with the modifiers. Modification of cullins by RUB
involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin
B/elonginC) -like E3 enzymes that are also involved in ubiquitination.
In contrast to ubiquitin, the UBLs do not seem to form multi-UBL
chains. UCRP(ISG15) resembles two ubiquitin moieties linked headto-
tail. Whether HUB1 functions as a modifier is currently unclear.
APG12 and URM1 are distinct from the other modifiers because
they are unrelated in sequence to ubiquitin. Data contributed by
S.Jentsch, see references above. Rabbit Serum Ce, Hu, Ms, Ze E, IP, WB
0.1 ml / €450.00
  Acris Antibodies GmbH

RBX1 / RNF75 antibody

RBX1 / RNF75 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

RBX1 / RNF75 antibody

RBX1 / RNF75 Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

RBX1 / RNF75 antibody

RBX1 / RNF75 Hu, Ms
0.1 ml / €560.00
  Abnova Taiwan Corp.

RBX1 / RNF75 antibody

Immunohistochemical staining of RBX1 on formalin fixed, paraffin embedded human tonsil with RBX1 polyclonal antibody. Rabbit Hu P
0.1 ml / €390.00
  Abnova Taiwan Corp.

RBX1 / RNF75 antibody

RBX1 / RNF75 Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt
0.1 mg / €310.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

RBX1 - human gene knockout kit via CRISPR

RBX1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

RBX1 - human gene knockout kit via CRISPR

RBX1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RBX1 - human gene knockout kit via CRISPR

RBX1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rbx1 - mouse gene knockout kit via CRISPR

Rbx1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Rbx1 - mouse gene knockout kit via CRISPR

Rbx1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rbx1 - mouse gene knockout kit via CRISPR

Rbx1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rbx1 - mouse gene knockout kit via CRISPR

Rbx1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RBX1 / RNF75

RBX1 / RNF75 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

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