RBX1 / RNF75 antibody

Principal name

RBX1 / RNF75 antibody

Alternative names for RBX1 / RNF75 antibody

Protein ZYP, ROC1, E3 ubiquitin-protein ligase RBX1, RING finger protein 75, RING-box protein 1, Regulator of cullins 1

SwissProt ID

O13959 (Schpo), P62877 (Human), P62878 (Mouse), Q08273 (Yeast), Q23457 (Caeel)

Gene ID

9978 (RBX1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Ce (C. elegans), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of RBX1 / RNF75 antibody

E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

General readings

Zheng, N., et al., (2002) Nature 416 (6882), 703-709.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RBX1 / RNF75 antibody

Human tonsil stained with Anti-ROC1 Rabbit Purified Hu, Ms P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

RBX1 / RNF75 antibody

Human tonsil stained with Anti-ROC1 Rabbit Purified Hu, Ms P, WB
1 ml / €440.00
  Acris Antibodies GmbH

RBX1 / RNF75 antibody

Human tonsil stained with Anti-ROC1 Rabbit Purified Hu, Ms P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

RBX1 / RNF75 antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Liver. Rabbit Hu E, IP, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

RBX1 / RNF75 (C-term) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Purified Hu, Ms P
0.25 ml / €470.00
  Acris Antibodies GmbH

RBX1 / RNF75 (C-term) antibody

Figure 1. Conjugation pathways for ubiquitin and
ubiquitin-like modifiers (UBLs). Most modifiers mature by
proteolytic processing from inactive precursors (a; amino acid).
Arrowheads point to the cleavage sites. Ubiquitin is expressed either
as polyubiquitin or as a fusion with ribosomal proteins. Conjugation
requires activating (E1) and conjugating (E2) enzymes that form
thiolesters (S) with the modifiers. Modification of cullins by RUB
involves SCF(SKP1/cullin-1/F-box protein) /CBC(cullin-2/elongin
B/elonginC) -like E3 enzymes that are also involved in ubiquitination.
In contrast to ubiquitin, the UBLs do not seem to form multi-UBL
chains. UCRP(ISG15) resembles two ubiquitin moieties linked headto-
tail. Whether HUB1 functions as a modifier is currently unclear.
APG12 and URM1 are distinct from the other modifiers because
they are unrelated in sequence to ubiquitin. Data contributed by
S.Jentsch, see references above. Rabbit Serum Ce, Hu, Ms, Ze E, IP, WB
0.1 ml / €440.00
  Acris Antibodies GmbH

RBX1 / RNF75 antibody

RBX1 / RNF75 Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

RBX1 / RNF75 antibody

RBX1 / RNF75 Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

RBX1 / RNF75 antibody

RBX1 / RNF75 Hu, Ms
0.1 ml / €560.00
  Abnova Taiwan Corp.

RBX1 / RNF75 antibody

Immunohistochemical staining of RBX1 on formalin fixed, paraffin embedded human tonsil with RBX1 polyclonal antibody. Rabbit Hu P
0.1 ml / €390.00
  Abnova Taiwan Corp.

RBX1 / RNF75 antibody

RBX1 / RNF75 Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt
0.1 mg / €310.00
  AVIVA Systems Biology

RBX1 / RNF75 antibody

Immunohistochemistry-Paraffin: RBX1 Antibody [NBP1-88742] - Immunohistochemical staining of human cerebellum shows nuclear positivity in Purkinje cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RBX1 / RNF75

RBX1 / RNF75 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

RBX1 / RNF75

RBX1 / RNF75 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

RBX1 / RNF75

RBX1 / RNF75 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

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