REG1A antibody

Principal name

REG1A antibody

Alternative names for REG1A antibody

REG1A, PSPS, REG, Lithostathine-1-alpha, Pancreatic stone protein, PSP, Pancreatic thread protein, PTP, Islet of Langerhans regenerating protein, Regenerating protein I alpha, Islet cells regeneration factor, ICRF

SwissProt ID

P05451 (Human)

Gene ID

5967 (REG1A)

Available reactivities

Hu (Human)

Available hosts

Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of REG1A antibody

Reg protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Regrelated proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Regrelated proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggest that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. human REG cDNA which encoded a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein. Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta. In patients with chronic hypergastrinemia, Reg production is stimulated, with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa, partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls, and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholithiasis, and various cancers of the digestive system.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

REG1A antibody

Immunohistochemical analysis of paraffin-embedded human Pancreas tissues using REG1A antibody Cat.-No AM06344SU-N Mouse IgG1 1A4 Ascites Hu E, ICC/IF, P
0.1 ml / €400.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

REG1A - human gene knockout kit via CRISPR

REG1A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

REG1A - human gene knockout kit via CRISPR

REG1A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

REG1A - human gene knockout kit via CRISPR

REG1A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

REG1A - human gene knockout kit via CRISPR

REG1A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

REG1A

  Recombinant protein of human regenerating islet-derived 1 alpha (REG1A)  
REG1A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

REG1A

  Recombinant protein of human regenerating islet-derived 1 alpha (REG1A)  
REG1A Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €299.00
  OriGene Technologies, Inc.

REG1A (His-tagged Fusion Protein)

12% SDS-PAGE separation of Human REG1 alpha  1. M.W. marker - 14, 21, 31, 45, 66, 97 kDa / 2. reduced and heated sample, 2.5µg/lane /  3. non-reduced and non-heated sample, 2.5µg/lane Human Purified > 95 % Determined by densitometric image analysis E. coli
0.1 mg / €470.00
  Acris Antibodies GmbH

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, REG1A (mGFP-tagged) - Human regenerating islet-derived 1 alpha (REG1A), 200 uL, >10^7 TU/mL

Lenti ORF particles, REG1A (mGFP-tagged) - Human regenerating islet-derived 1 alpha (REG1A), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, REG1A (Myc-DDK tagged) - Human regenerating islet-derived 1 alpha (REG1A) , 200 uL, >10^7 TU/mL

Lenti ORF particles, REG1A (Myc-DDK tagged) - Human regenerating islet-derived 1 alpha (REG1A) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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