RELB / I-Rel antibody

Principal name

RELB / I-Rel antibody

Alternative names for RELB / I-Rel antibody

Rel B, Transcription factor RelB

SwissProt ID

P51509 (Chick), P51510 (Xenla), Q01201 (Human), Q04863 (Mouse)

Gene ID

5971 (RELB), 395971 (ADORA2B)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Frozen Sections (C)

Background of RELB / I-Rel antibody

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49.

General readings

1. Marienfeld R, et al. (2001) Oncogene. 20 (56): 8142 - 7.
(see:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Marienfeld+R%22%5BAuthor%5D)
2. Charlotte S. Kaetzel1, et al. (2005) Immunological Reviews Volume 206: 83
3. Elwira Pyz, et al. (2006) J Immunol. 176:7447 - 55

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RELB / I-Rel antibody

Western blot analysis of extracts from HeLa cells, using RelB (Ab-552) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RELB / I-Rel antibody

Western blot analysis of RelB expression in HepG2 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RELB / I-Rel antibody

WB Suggested Anti-RELB Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:7812500; Positive Control: THP-1 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

RELB / I-Rel antibody

WB Suggested Anti-RELB Antibody Titration: 1.25ug/ml; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RELB / I-Rel antibody

RELB / I-Rel Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RELB / I-Rel antibody

WB Suggested Anti-RELB Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Human brain Rabbit IgG Purified Can, GP, Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

RELB / I-Rel antibody

WB Suggested Anti-RELB Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Can, Eq, Hu, Por WB
50 µg / €325.00
  OriGene Technologies, Inc.

RELB / I-Rel pSer552 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using RelB antibody (AP02507PU-S; AP02507PU-N). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

RELB / I-Rel pSer552 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using RelB antibody (AP02507PU-S; AP02507PU-N). Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €240.00
  Acris Antibodies GmbH

RELB / I-Rel antibody

Western blot analysis of extracts from A431 cells, untreated or treated with EGF (200ng/ml 10min), using RelB antibody (Line 1 and 2) and RelB (pSer552) antibody (Line 3 and 4). Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €270.00
  Acris Antibodies GmbH

RELB / I-Rel antibody

Western blot analysis of extracts from A431 cells, untreated or treated with EGF (200ng/ml 10min), using RelB antibody (Line 1 and 2) and RelB (pSer552) antibody (Line 3 and 4). Rabbit Aff - Purified Hu, Ms WB
50 µl / €230.00
  Acris Antibodies GmbH

RELB / I-Rel antibody

Tonsil: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

RELB / I-Rel antibody

RELB / I-Rel Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

RELB / I-Rel antibody

RELB / I-Rel Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

RELB / I-Rel antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between RELB and RELA HeLa cells were stained with anti-RELB rabbit purified polyclonal 1:1200 and anti-RELA mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

RELB / I-Rel pSer552 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using RelB (Phospho-Ser552) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
50 µg / €205.00
  Assay Biotech

RELB / I-Rel pSer552 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using RelB (Phospho-Ser552) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €310.00
  Assay Biotech

RELB / I-Rel antibody

Western blot analysis of extracts from HeLa cells, using RelB (Ab-552) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

RELB / I-Rel antibody

Western blot analysis of extracts from HeLa cells, using RelB (Ab-552) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

RELB / I-Rel antibody

Human Thymus; WB Suggested Anti-RELB Antibody Titration: 2.5ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Thymus; RELB antibody - middle region (ARP36969_T100) in Human Thymus cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €310.00
  AVIVA Systems Biology

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