RELM beta antibody

Principal name

RELM beta antibody

Alternative names for RELM beta antibody

Resistin-like beta, RELMbeta, RELM-beta RETNLB, CCRG, FIZZ2, HXCP2, RETNL2, Cysteine-rich secreted protein FIZZ2, Colon and small intestine-specific cysteine-rich protein, Cysteine-rich secreted protein A12-alpha-like 1, Colon carcinoma-related gene protein

SwissProt ID

Q99P86 (Mouse), Q9BQ08 (Human)

Gene ID

57263 (Retnlb), 84666 (RETNLB), 984666 (murB)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Enzyme Immunoassay (E)

Background of RELM beta antibody

Adipose tissue is an energy reserve that is strictly regulated in animals. Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), perilipin, and resistin. Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine that is specifically secreted by adipocytes. While the function of resistin is not well understood, it appears to have key paracrine roles and has a suggested role in type 2 diabetes. Studies show that in obese, diabetic mice the levels of serum resistin are increased, which has an antagonistic effect on insulin. Additional studies have shown that resistin causes insulin resistance and glucose intolerance in mice.
Resistin gene expression requires C/EBP alpha, which is necessary and sufficient for expression. Studies show that the coactivators CBP and p300, which have been shown to display histone acetyltransferase (HAT) activity, abundantly acetylate the histones at the resistin promoter suggesting their role in activating chromatin for resistin transcription. Numerous PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.

General readings

Zaph, C. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature.;446(7135):552-6 3/29/2007 17322906
Wilson E.H. B7RP-1-ICOS interactions are required for optimal infection-induced expansion of CD4+ Th1 and Th2 responses. Journal of Immunology;177(4):2365-72. 8/15/2006 16887998
Nair MG Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy. J Immunol. ;177(3):1393-9 8/1/2006 16849442
Zaph C. Persistence and function of central and effector memory CD4+ T cells following infection with a gastrointestinal helminth. Journal of Immunology;177(1):511-8. 7/1/2006 16785548
Artis D. New weapons in the war on worms: Identification of putative mechanisms of immune-mediated expulsion of gastrointestinal nematodes. Int J Parasitol.;36(6):723-33. 5/31/2006 16620826

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RELM beta antibody

(2.5g/ml) staining of paraffin embedded Human Colon. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Hu E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

Western blot analysis of RELM-beta using recombinant human RELM-beta. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and cervical cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human colon cancer tissue using RETNLB antibody at dilution 1/40, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

Predicted cell location: Cytoplasm. Positive control: Human liver and ovarian cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human liver cancer tissue using RETNLB antibody at dilution 1/20, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

To detect Human RELMbeta by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Human RELMbeta. Rabbit IgG Purified Hu E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

To detect Human RELMbeta by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Human RELMbeta (TA328433) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Human RELMbeta. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

To detect Murine RELMbeta by direct ELISA (using 100 ul/well antibody solution) a concentration of 0.25-1.0 ug/ml of this antibody is required.  This biotinylated polyclonal antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2-0.4 ng/well of recombinant Murine RELMbeta. Rabbit IgG Purified E, WB
50 µg / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

To detect Murine RELMbeta by sandwich ELISA (using 100 ul/well antibody solution) a concentration of 0.5 - 2.0 ug/ml of this antibody is required. This antigen affinity purified antibody, in conjunction with Biotinylated Anti-Murine RELMbeta (TA328552) as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant Murine RELMbeta. Rabbit IgG Purified E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

WB Suggested Anti-RETNLB Antibody; Titration: 1.0 ug/ml; Positive Control: A549 Whole Cell Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

RELM beta antibody

Direct ELISA using RELM beta Antibody Cat.-No AP01134BT Rabbit Biotin Ms E, WB
50 µg / €340.00
  Acris Antibodies GmbH

RELM beta antibody

Direct ELISA using RELM beta Antibody Cat.-No AP01134BT Rabbit Biotin Ms E, WB
25 µg / €230.00
  Acris Antibodies GmbH

RELM beta antibody

RELM beta Rabbit Aff - Purified Ms E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

RELM beta antibody

RELM beta Rabbit Aff - Purified Ms E, WB
50 µg / €230.00
  Acris Antibodies GmbH

RELM beta (Internal) antibody

Human Small Intestine (formalin-fixed, paraffin-embedded) stained with RETNLB antibody AP22581PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Hu, Mky E, P
50 µg / €470.00
  Acris Antibodies GmbH

RELM beta antibody

RELM beta Rabbit Biotin Hu E, WB
25 µg / €230.00
  Acris Antibodies GmbH

RELM beta antibody

RELM beta Rabbit Biotin Hu E, WB
50 µg / €340.00
  Acris Antibodies GmbH

RELM beta antibody

RELM beta Rabbit Aff - Purified Hu E, WB
50 µg / €240.00
  Acris Antibodies GmbH

RELM beta antibody

RELM beta Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Acris Antibodies GmbH

RELM beta antibody

RELM beta Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

RELM beta antibody

RELM beta Rabbit Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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