Respiratory Syncytial Virus / RSV antibody

Principal name

Respiratory Syncytial Virus / RSV antibody

Available reactivities

Rt (Rat), Vi (Virus), Hu (Human), Ms (Mouse), Bov (Bovine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Western blot / Immunoblot (WB), Neutralisation (NEUT), Paraffin Sections (P), Flow Cytometry (F), Immunoelectron Microscopy (EM), Immunoprecipitation (IP), Functional assay (FN), Radioimmunoassay (R), Lateral Flow (LF)

Background of Respiratory Syncytial Virus / RSV antibody

Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein is a Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (protein F) interacts with glycoprotein G at the virion surface. Upon binding of G to heparan sulfate, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between host cell and virion membranes. Notably, RSV fusion protein is able to interact directly with heparan sulfate and therefore actively participates in virus attachment. Furthermore, the F2 subunit was identifed as the major determinant of RSV host cell specificity. Later in infection, proteins F expressed at the plasma membrane of infected cells mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis. The fusion protein is also able to trigger p53-dependent apoptosis.

General readings

1 Chanock, R. M., and L. Finberg. 1957. Recovery from infants with respiratory illness of a virus related to chimpanzee coryza agent (CCA). II. Epidemiologic aspects of infection in infants and young children. Am. J. Hyg. 66:291-300.
2 Chanock, R. M., H. W. Kim, A. J. Vargosko, A. Deleva, K. M. Johnson, C. Cumming, and R. H. Parrott. 1961. Respiratory syncytial virus. I. Virus recovery and other observations during 1960 outbreak of bronchiolitis, pneumonia, and minor respiratory diseases in children. J. Am. Med. Assoc. 176:647-653.
3 Hall, C. B., R. G. Douglas, and J. M. Geiman. 1976. Respiratory syncytial virus infections in infants; quantitation and duration of shedding. J. Pediatr. 89:1-15.
4 Manual of Clinical Microbiology.-5th ed.: editor in chief, Albert Balows; editors, William J. Hausler, Jr.et al.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Respiratory Syncytial Virus / RSV (Type A and B) antibody

Respiratory Syncytial Virus / RSV Goat Ig Fraction C, E, ICC/IF, WB
1 ml / €440.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV strain Long (Fusion protein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG1 BDI064 Purified E, ICC/IF, NEUT
1 mg / €740.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV strain Long (Fusion protein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2a BDI065 Purified E, ICC/IF, NEUT
1 mg / €740.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV bovine and human strains (Nucleoprotein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG1 B023 Purified C, E
1 mg / €940.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Fusion protein F2) antibody

Respiratory Syncytial Virus / RSV Mouse IgG1 2017/84 Purified E, WB
0.2 mg / €360.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Fusion protein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2a 0651 Purified E, ICC/IF
0.1 mg / €410.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Fusion protein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2b 0681 Purified E, ICC/IF
0.1 mg / €340.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Fusion protein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2a 0631 Purified E, ICC/IF
0.1 mg / €340.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (33kDa + 190 kDa) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2a B694M Azide Free E, ICC/IF, LF, WB
1 mg / €710.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV Fusion Protein antibody

Respiratory Syncytial Virus / RSV Mouse IgG2b RSV3216 (B016) Purified ICC/IF
1 mg / €780.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Glycoprotein G) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2b 9B6 Purified E, ICC/IF, WB
0.2 mg / €330.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Fusion protein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2b 10B6 Purified E, F, ICC/IF
0.2 mg / €330.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Type A and B) antibody

Respiratory Syncytial Virus / RSV Mouse cocktail (4 clone blend) Supernatant C, ICC/IF, P, WB
0.25 ml / €440.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV strain Long (Fusion protein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2a 631 Purified E, ICC/IF
1 mg / €740.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Nucleoprotein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2 671 Purified E, ICC/IF
1 mg / €710.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Nucleoprotein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG2 671 FITC ICC/IF
0.1 mg / €480.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV strain Long (Fusion protein) antibody

Respiratory Syncytial Virus / RSV Mouse IgG 681 Purified E, ICC/IF
1 mg / €740.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Type A and B) antibody

Respiratory Syncytial Virus / RSV Goat Biotin E, WB
1 ml / €410.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Type A and B) antibody

Respiratory Syncytial Virus / RSV Goat FITC ICC/IF
1 ml / €410.00
  Acris Antibodies GmbH

Respiratory Syncytial Virus / RSV (Type A and B) antibody

Respiratory Syncytial Virus / RSV Goat HRP E, NEUT, P
1 ml / €460.00
  Acris Antibodies GmbH

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