Reticulon 1 / RTN1 antibody

Principal name

Reticulon 1 / RTN1 antibody

Alternative names for Reticulon 1 / RTN1 antibody

Reticulon-1, RTN1, NSP, Neuroendocrine-specific protein

SwissProt ID

Q04947 (Yeast), Q16799 (Human), Q16799-2, Q64548 (Rat), Q8K0T0 (Mouse), Q9BQ59 (Human)

Gene ID

6252 (RTN1), 104001 (Rtn1), 116644

Available reactivities

Hst (Hamster), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Rb (Rabbit), Por (Porcine), Bov (Bovine), Chk (Chicken), Ze (Zebrafish), African clawed frog, Can (Canine), GP (Guinea Pig), Eq (Equine), Sh (Sheep)

Available hosts

Mouse, Rabbit

Available applications

Flow Cytometry (F), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Reticulon 1 / RTN1 antibody

Recently, a novel gene family has been identified and characterized, designated the Reticulons because the proteins encoded by these genes are anchored to the membranes of the endoplasmic reticulum. Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues. The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22. The NSP-gene encodes three overlapping proteins, i.e. Reticulon-1A (NSPA), Reticulon-1B (NSP-B), and Reticulon-1C (NSPC). These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions. Reticulon-1A is a protein with a molecular weight (MW) of about 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues. In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A. Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82. Reticulon-1B is so far not found in human tissues. Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non- SCLC (cell cultures). The epitope of MON-162 is located between amino acid residues 338-422 of Reticulon-1A.

General readings

Di (2007) J. Neurochem. 102 (2), 345-353

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Reticulon 1 / RTN1 antibody

  Rabbit Polyclonal Anti-RTN1 Antibody  
WB Suggested Anti-RTN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: 293T cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

Reticulon 1 / RTN1 antibody

  Rabbit Polyclonal Anti-RTN1 Antibody  
WB Suggested Anti-RTN1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Sh, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

Reticulon 1 / RTN1 (Isoform RTN1-A) antibody

Reticulon 1 / RTN1 Mouse IgG1 MON160 Purified Hst, Hu, Ms, Rt C, F, ICC/IF, P, WB
0.1 mg / €340.00
  OriGene Technologies GmbH

Reticulon 1 / RTN1 (Isoform RTN1-A) antibody

Reticulon 1 / RTN1 Mouse IgG1 MON161 Purified Hst, Hu, Ms, Rt C, F, ICC/IF, P, WB
0.1 mg / €340.00
  OriGene Technologies GmbH

Reticulon 1 / RTN1 (Isoform RTN1-A) antibody

Reticulon 1 / RTN1 Mouse IgG1 MON162 Purified Hst, Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €340.00
  OriGene Technologies GmbH

Reticulon 1 / RTN1 (Isoform RTN1-A/B) antibody

Reticulon 1 / RTN1 Mouse IgG1 RNL-2 Purified Hu, Mky, Rb C, F, ICC/IF, P, WB
0.1 mg / €340.00
  OriGene Technologies GmbH

Reticulon 1 / RTN1 (Isoform RTN1-A/B) antibody

Reticulon 1 / RTN1 Mouse IgG1 RNL-3 Purified Hu, Mky, Rb C, F, ICC/IF, P, WB
0.1 mg / €340.00
  OriGene Technologies GmbH

Reticulon 1 / RTN1 (Isoform RTN1-C) antibody

Immunoblotting of RNL-4 recognizing NSP-C Reticulon 1-C (23 kDa) in extract from neuroblastoma cell line LA-N-5. Mouse IgG1 RNL-4 Purified Hu, Por, Rt C, F, ICC/IF, WB
0.1 mg / €340.00
  OriGene Technologies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Reticulon 1 / RTN1 (transcript variant 1)

  Recombinant protein of human reticulon 1 (RTN1), transcript variant 1  
Reticulon 1 / RTN1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Reticulon 1 / RTN1 (transcript variant 3)

  Recombinant protein of human reticulon 1 (RTN1), transcript variant 3  
Reticulon 1 / RTN1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

RTN1 overexpression lysate

RTN1 overexpression lysate  
0.1 mg / €295.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Rtn1 (GFP-tagged) - Mouse reticulon 1 (Rtn1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Rtn1 (GFP-tagged) - Mouse reticulon 1 (Rtn1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,535.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rtn1 (GFP-tagged) - Mouse reticulon 1 (Rtn1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Rtn1 (GFP-tagged) - Mouse reticulon 1 (Rtn1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €907.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rtn1 (Myc-DDK-tagged) - Mouse reticulon 1 (Rtn1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Rtn1 (Myc-DDK-tagged) - Mouse reticulon 1 (Rtn1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,381.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rtn1 (Myc-DDK-tagged) - Mouse reticulon 1 (Rtn1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Rtn1 (Myc-DDK-tagged) - Mouse reticulon 1 (Rtn1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €804.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Rtn1 (GFP-tagged ORF) - Rat reticulon 1 (Rtn1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rtn1 (GFP-tagged ORF) - Rat reticulon 1 (Rtn1), 200 uL, >10^7 TU/mL  
200 µl / €1,525.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rtn1 (Myc-DDK-tagged ORF) - Rat reticulon 1 (Rtn1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rtn1 (Myc-DDK-tagged ORF) - Rat reticulon 1 (Rtn1), 200 uL, >10^7 TU/mL  
200 µl / €1,375.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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