RFFL / RNF189 antibody

Principal name

RFFL / RNF189 antibody

Alternative names for RFFL / RNF189 antibody

CARP2, CARP-2, Fring, RNF34L, RIFIFYLIN, E3 ubiquitin-protein ligase rififylin, Caspases-8 and -10-associated RING finger protein 2, FYVE-RING finger protein Sakura, RING finger protein 189, RING finger protein 34-like

SwissProt ID

Q6ZQM0 (Mouse), Q8CIN9 (Rat), Q8WZ73 (Human)

Gene ID

117584 (RFFL), 67338 (Rffl), 282844

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of RFFL / RNF189 antibody

RFFL, also known as Rififylin, RING finger and FYVE-like domaincontaining protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like, is a novel modulator of NF-kappaB activation. RFFL possesses E3 ubiquitin protein ligase activity and has been shown to regulate the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. RFFL also possesses anti-apoptotic activity and may bind phosphatidylinositol phosphates. RFFL is a membrane bound cytoplasmic protein that is expressed ubiquitously. RFFL can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes and is rapidly degraded after stimulation with TNFSF10, and probably by caspases. Multiple transcript variants have been detected for this protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RFFL / RNF189 antibody

  Rabbit polyclonal anti-RFFL antibody  
WB using anti-RFFL antibody shows detection of RFFL (arrowhead) in lysate. Lanes correspond to empty vector 293T cell lysate (mock, left); RNF34 transfected lysate (middle) and RFFL transfected lysate (right), are shown using 20 µl of lysate per lane. Lysates were prepared from equivalent numbers of cells. Data presented demonstrate that this reagent is specific for RFFL. Primary antibody was used at a 1:1,000 dilution. Rabbit IgG Purified Bov, Can, Hu, Ms, Rt E, P, WB
0.5 mg / €590.00
  OriGene Technologies, Inc.

RFFL / RNF189 antibody

  Rabbit Polyclonal anti-RFFL antibody  
RFFL / RNF189 Rabbit IgG Purified Hu WB
0.1 ml / €360.00
  OriGene Technologies, Inc.

RFFL / RNF189 antibody

  Rabbit Polyclonal Anti-RFFL Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (RFFL Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €335.00
  OriGene Technologies, Inc.

RFFL / RNF189 (1-363) antibody

Figure 1. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cortex. Rabbit Purified Hu E, ICC/IF, P, WB
50 µg / €425.00
  OriGene Technologies GmbH

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