RGS18 antibody

Principal name

RGS18 antibody

Alternative names for RGS18 antibody

RGS13, Regulator of G-protein signaling 18

SwissProt ID

Q4L0E8 (Rat), Q99PG4 (Mouse), Q9NS28 (Human)

Gene ID

64407 (RGS18), 64214 (Rgs18)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine)

Available hosts

Chicken, Mouse, Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of RGS18 antibody

**Please note, this product is one of a range of Investigative Grade antibodies, made against targets that have limited or no commercial antibodies available to them and for which there are no data on the expression of the protein in the range of common cell lines and tissues available to us. These antibodies are affinity purified using their peptide immunogen and are known to give low background staining in a western blot. However no additional claims are made for their ability to recognise native protein in any application.

Regulators of G-protein signaling (RGSs) are a protein family that can act as GTPase-activating proteins for G(alphai)- and G(alphaq)-class proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination. One of these proteins, RGS18, is a 235 amino acid protein that is closely related to RGS5 (46% identity) and approximately 30-40% identity to other RGS proteins. This protein is expressed in platelet, leukocyte, and megakaryocyte cell lines. Engagement of TLR3 or TLR4 on monocyte-derived DCs potently down-regulates RGS18 and RGS14 without modifying other RGS proteins. A similar pattern of RGS protein expression occurs in immature bone marrow-derived mouse DCs stimulated to mature via TLR4 signaling. The changes in RGS18 and RGS1 expression are likely important for DC function.

General readings

1. Park IK, Klug CA, Li K, Jerabek L, Li L, Nanamori M, Neubig RR, Hood L, Weissman IL, Clarke MF.
Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells.
J Biol Chem. 2001 Jan 12;276(2):915-23. PMID: 11042171

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RGS18 (C-term) antibody

TA305725 (1ug/ml) staining of Human Peripheral Blood Mononucleocytes lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RGS18 antibody

Western Blot: RGS18 Antibody [TA336471] - Analysis of RGS18 in human lung lysate using this antibody at a dilution of 2 ug/ml. Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RGS18 antibody

Western Blot: RGS18 Antibody [TA336970] - Western blot analysis of RGS18 in 1) transfected 293T cells and 2) untransfected 293T cells using TA336970 at 1:500. Rabbit Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RGS18 antibody

Western Blot analysis of RGS18 expression in transfected 293T cell line (H00064407-T01) by RGS18 MaxPab polyclonal antibody.

Lane 1: RGS18 transfected lysate(25.96 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

RGS18 antibody

Western Blot analysis of RGS18 expression in transfected 293T cell line (H00064407-T02) by RGS18 MaxPab polyclonal antibody.

Lane 1: RGS18 transfected lysate(25.85 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

RGS18 antibody

RGS18 Mouse IgG 1H6 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

RGS18 antibody

RGS18 Mouse IgG1 1G12 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

RGS18 antibody

Western blot analysis of RGS18 in human lung lysate. Using RGS18 polyclonal antibody ( Cat # PAB0228 ) at a dilution of 2 µg/ml. Rabbit Hu WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

RGS18 antibody

RGS18 Goat Hu E
0.1 mg / €400.00
  Abnova Taiwan Corp.

RGS18 antibody

Human Thymus; WB Suggested Anti-RGS18 Antibody Titration: 5.0ug/ml. Positive Control: Human Thymus; RGS18 antibody - N-terminal region (ARP42804_T100) in Human Thymus cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

RGS18 antibody

RGS18 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

RGS18 (N-term) antibody

RGS18 Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

RGS18 antibody

Western Blot: E coli-derived fusion protein as test antigen. Affi-pure IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-RGS18 ) Chicken Aff - Purified Hu, Ms, Rt WB
50 µg / €520.00
  Novus Biologicals Inc.

RGS18 antibody

RGS18 Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

RGS18 antibody

Immunohistochemistry-Paraffin: RGS18 Antibody [NBP1-92329] Immunohistochemical staining of human bone marrow shows strong nuclear positivity in megakaryocytes. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RGS18 (full length, N-term HIS tag)

RGS18 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

RGS18 (C-term)

RGS18 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

RGS18 (C-term)

RGS18 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

RGS18 293T Cell Transient Overexpression Lysate(Denatured)

RGS18 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

RGS18 293T Cell Transient Overexpression Lysate(Denatured)

RGS18 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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