Rhodopsin antibody

Principal name

Rhodopsin antibody

Alternative names for Rhodopsin antibody

RHO, Opsin-2, OPN2

SwissProt ID

O16005 (Sepof), O16017 (Camlu), O16018 (Camsc), O16019 (Orcvi), O16020 (Proml), O18312 (Camhu), O18315 (Camma), O18481 (Orcau), O18485 (Proor), O18486 (Prose), O18766 (Pig), O42268 (Ictpu), O42294 (Abyko), O42300 (Batmu), O42301 (Batni), O42307 (Cotbo), O42327 (Comdy), O42328 (Cotgr), O42330 (Cotin), O42427 (Limbe), O42431 (Limpa), O42451 (Proje), O42452 (Parkn), O42466 (Taubu), O42604 (Zeufa), O62791 (Delde), O62792 (Glome), O62793 (Mesbi), O62794 (Phovi), O62795 (Paggo), O62796 (Trima), O62798 (Turtr), O93441 (Galml), O93459 (Scyca), P02699 (Bovin), P02700 (Sheep), P08100 (Human), P09241 (Entdo), P15409 (Mouse), P22328 (Chick), P22671 (Lamja), P24603 (Lolfo), P28681 (Crigr), P29403 (Xenla), P31355 (Ranpi), P31356 (Todpa), P32308 (Canfa), P32309 (Carau), P35356 (Procl), P35359 (Danre), P35362 (Sphsp), P35403 (Pommi), P41590 (Astfa), P41591 (Anoca), P49912 (Rabit), P51470 (Ranca), P51488 (Cypca), P51489 (Rat), P52202 (Allmi), P56514 (Bufbu), P56515 (Bufma), P56516 (Rante), P79756 (Gamaf), P79798 (Myrbe), P79807 (Myrvi), P79808 (Neoar), P79809 (Neoau), P79812 (Neosa), P79848 (Poere), P79863 (Leuer), P79898 (Sardi), P79901 (Sarmi), P79902 (Sarpu), P79903 (Sarsp), P79911 (Sarti), P79914 (Sarxa), P87369 (Oryla), Q17053 (Apime), Q17094 (Lolsu), Q17292 (Camab), Q17296 (Catbo), Q28886 (Macfa), Q68J47 (Loxaf), Q6W3E1 (Calpd), Q769E8 (Otocr), Q8HY69 (Smicr), Q90245 (Ambti), Q90305 (Corau), Q90373 (Cotke), Q95KU1 (Felca), Q98980 (Petma), Q9DGG4 (Tetng), Q9YGY9 (Zosop), Q9YGZ0 (Sarpi), Q9YGZ1 (Athbo), Q9YGZ2 (Gobni), Q9YGZ3 (Salpv), Q9YGZ4 (Dicla), Q9YGZ5 (Solso), Q9YGZ6 (Lizau), Q9YGZ7 (Lizsa), Q9YGZ8 (Chelb), Q9YGZ9 (Mugce), Q9YH00 (Litmo), Q9YH01 (Mulsu), Q9YH02 (Spaau), Q9YH03 (Sarsl), Q9YH04 (Dipvu), Q9YH05 (Dipan)

Gene ID

6010 (RHO), 24717 (Rho), 509933

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mam (Mammalia), Av (Birds), Amph (Amphibian), Bov (Bovine), Fi (Fish), Frog, Por (Porcine), Ze (Zebrafish), Ve (Vertebrates), Fe (Feline), Mky (Monkey), Rb (Rabbit), Can (Canine), GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Rhodopsin antibody

Rhodopsin is the protein in the mammalian reti responsible for the light sensitivity of rod cells, which are responsible for vision in low light levels. Somewhat surprisingly, the Rhodopsin protein turned out to be a typical member of the seven transmembrane G protein-coupled receptor (GPCR) superfamily. Whereas other GPCRs initiate sigling on binding a specific ligand, Rhodopsin exists with a ligand already bound, specifically the vitamin A related substance retil. Retil can exist in two isomeric forms, 11-cis and 11-trans retil. In the dark Rhodopsin is associated with 11-cis retil, but photons cause the 11-cis form to flip to the 11-trans form, and this causes an alteration in the structure of the Rhodopsin making it catalytically active. Activated Rhodopsin in turn activates the GTP binding protein transducin by favoring the loss of GDP and the addition of GTP. Transducin is a typical member of the family of heterotrimeric G proteins, and consists of an alpha and a beta gamma subunit. The alpha subunit is responsible for the GTP binding and the GTP bound form activates a phosphodiesterase (PDE) enzyme which hydrolysescyclic GMP. This in turn results in the closure of cyclic nucleotide gated ion channels in the rod cell membrane, which prevent the influx of sodium and calcium ions. This results in an increase in the membrane potential of the rod cell and so reduces the rate of syptic sigling. So light stimulation results in a reduced rate of photoreceptor syptic release. This information is transmitted through neurons of the reti to the visual centers of the brain. Rhodopsin activity is shut off by phosphorylation under the influence of Rhodopsin kise, the activity of which results in binding of visual arrestin, which prevents Rhodopsin from interacting with and activating more transducin molecules. This basic sigling paradigm proved to be a prototype for understanding how other GPCRs function, as proteins similar to transducin, arrestin and rhodopsin kise are found in these pathways.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Rhodopsin (C-term) antibody

  Mouse Monoclonal anti-RHO Antibody  
Western blot analysis of Rhodopsin in human cell lines using a 1:1000 dilution of anti-RHO. Mouse IgG1 1D4 Purified Ve, Vertebrates. C, E, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Rhodopsin antibody

  Mouse Anti-Rhodopsin Antibody  
Immunohistochemical staining of mouse retinal section showing specific immunolabeling of the rhodopsin protein in the rod spherules. Photo courtesy of Mary Raven, University of California, Santa Barbara, CA. Mouse IgG1 1D4 Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Rhodopsin (N-term) antibody

  Mouse Monoclonal anti-RHO Antibody  
Immunofluorescence of Rho using a dilution of Rhodopsin antibody Mouse IgG1 4D2 Purified Amph, Bov, Fi, Frog, Hu, Mam, Ms, Por, Rt, Ze C, E, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Rhodopsin antibody

  Rabbit polyclonal anti-RHO (rhodopsin) antibody  
Western blot analysis of extracts from A549 cells, using RHO antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Rhodopsin antibody

  Mouse Monoclonal Rhodopsin Antibody (A531)  
Western Blot: Rhodopsin Antibody (A531) [TA337112] - Blot of bovine retinal extracts. The antibody stains a band corresponing to retinal Rhodopsin at about 35kDa. Bands about 70 kDa and 140 kDa are aggregated forms of Rhodopsin. Note, due to the highly hy Mouse IgG1 A531 Purified Bov, Hu, Ms, Por, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Rhodopsin antibody

  Mouse Monoclonal Rhodopsin Antibody (B630)  
Western Blot: Rhodopsin Antibody (B630) [TA337113] - Blot of bovine retinal extracts. The antibody stains a band corresponing to retinal Rhodopsin at about 35kDa. Bands about 70 kDa and 140 kDa are aggregated forms of Rhodopsin. Note, due to the highly hy Mouse IgG1 B630 Purified Bov, Hu, Ms, Por, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Rhodopsin (2nd extracell. dom.) antibody

  Rabbit Polyclonal Anti-RHO Antibody (Extracellular Domain)  
Rhodopsin Rabbit Aff - Purified Elephant, Fe, Hu, Mky, Ms, Por, Rb, Rt, Ze P
50 µg / €400.00
  OriGene Technologies, Inc.

Rhodopsin antibody

  Rabbit Polyclonal Anti-RHO Antibody  
WB Suggested Anti-RHO Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Rhodopsin antibody

Immunohistochemistry (IHC) analyzes of Rhodopsin antibody (Cat.-No.: AP06577PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Rhodopsin pSer334 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Rhodopsin (Phospho-Ser334) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €230.00
  Assay Biotech

Rhodopsin pSer334 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using Rhodopsin (Phospho-Ser334) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €330.00
  Assay Biotech

Rhodopsin antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Rhodopsin (Ab-334) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

Rhodopsin antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Rhodopsin (Ab-334) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

RHO - human gene knockout kit via CRISPR

RHO - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

RHO - human gene knockout kit via CRISPR

RHO - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RHO - human gene knockout kit via CRISPR

RHO - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RHO - human gene knockout kit via CRISPR

RHO - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

RHO overexpression lysate

RHO overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, RHO (mGFP-tagged) - Human rhodopsin (RHO), 200 uL, >10^7 TU/mL

Lenti ORF particles, RHO (mGFP-tagged) - Human rhodopsin (RHO), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, RHO (Myc-DDK tagged) - Human rhodopsin (RHO) , 200 uL, >10^7 TU/mL

Lenti ORF particles, RHO (Myc-DDK tagged) - Human rhodopsin (RHO) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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