RICH2 antibody

Principal name

RICH2 antibody

Alternative names for RICH2 antibody

RICH-2, KIAA0672, Rho GTPase-activating protein RICH2, RhoGAP interacting with CIP4 homologs protein 2

SwissProt ID

Q17R89 (Human), Q5SSM3 (Mouse)

Gene ID

9912 (ARHGAP44), 216831 (Arhgap44)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)

Background of RICH2 antibody

RICH2, Rho GTPase-activating protein interacting with CIP homologue protein 2, is a member Rho GTPase activating protein RICH family. This family of protein is one of the major regulators of Rho GTPases in all eukaryotes (1). In addition to their role as specific negative regulators of Rho protein signaling pathways, they are crucial in the differentiation, growth and organization of cell cytoskeleton, neuronal development and synaptic functions (2). RICH2 is located at mouse chromosome 11B3 and as a GTPase activator for the Rho-type GTPases, it converts them to an inactive GDP-bound state. Recent reports have identified RICH2 as a GTPase activator for Cdc42 and Rac1 (3). RICH2 and different isoforms of RICH1 share two conserved domains, an N-terminal BAR domain and Rho/Rac/cdc42 GAP domain. The BAR domain of RICH2 binds membranes and is capable of inducing membrane tabulation (4). As a member of RICH family of proteins, RICH2 plays a crucial role in linking CD317/tetherin to the apical actin network (5).
Knocking down the expression of RICH2 in cells usually results in loss of apical actin network. These cells exhibited similar characteristics that were seen in the CD317 knockdown cells (5). These characteristics include subsequent loss of apical microvilli, increase in actin bundles at the basal surface, reduction in cell height without any loss of tight junctions or transepithelial resistance or any change in the distribution of apical and basolateral marker proteins. Overexpression of RICH2 leads to a loss of Ras-induced membrane ruffles (3). RICH2 is approximately a 125kDa protein (764 amino acids) (5).

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RICH2 Control Peptide

0.1 mg / €250.00
  Acris Antibodies GmbH

RICH2 (N-term) antibody

Western Blot of RICH2 antibody (Cat#AP09861PU-N) with Rec-proteins and Cell extracts at 1/500 dilution. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

RICH2 (C-term) antibody

Formalin fixed, paraffin embedded human brain tissue stained with RICH2 Antibody (C-term) Cat.-No AP53665PU-N followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

RICH2 antibody

RICH2 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

4 Item(s)

per page
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