RIT1 antibody

Principal name

RIT1 antibody

Alternative names for RIT1 antibody

RIBB, RIT, ROC1, Ras-like protein expressed in many tissues, Ras-like without CAAX protein 1

SwissProt ID

P23796 (Yeast), P70426 (Mouse), Q92963 (Human)

Gene ID

6016 (RIT1), 3560163 (argH)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Por (Porcine), Rb (Rabbit), Sh (Sheep), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of RIT1 antibody

Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation.Neuronal activity dramatically increases the concentration of cytosolic Ca2+, which then serves as a second messenger to direct diverse cellular responses. Calmodulin is a primary mediator of Ca2+ signals in the nervous system. Ric, a protein related to the Ras subfamily of small GTPases, has the ability to bind calmodulin. In addition, two Ras-like human proteins, Rin and Rit (Ric-related gene expressed in many tissues), which are 71% and 66% identical to RIC respectively, share related G2 domains with Ric. While most members of the Ras subfamily are plasma membrane-associated and generally require a C-terminal isoprenyl group to bind to the plasma membrane, Rit and Rin lack the recognition signal for C-terminal prenylation. Transiently expressed Rit and Rin are plasma membrane-localized because both proteins contain a C-terminal cluster of basic amino acids, which provides a mechanism for membrane association. Rin binds calmodulin through a C-terminal binding motif. Rit and Ric are widely expressed, whereas expression of Rin is restricted to the neuron system. In conclusion, Rit and Rin define a novel subfamily of Ras-related proteins

General readings

General / background references:Rusyn EV et al. Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways. Oncogene 19:4685-94 (2000). PubMed PMID: 11032018
Shao H et al. Biochemical characterization of the Ras-related GTPases Rit and Rin. Arch Biochem Biophys 371:207-19 (1999). PubMed PMID: 10545207
Lee CH et al. Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins. J Neurosci 16:6784-94 (1996). PubMed PMID: 8824319

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RIT1 antibody

Western blot analysis of extracts from Jurkat cells, using RIT1 antibody (#TA314447).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RIT1 antibody

Host: Rabbit; Target Name: Rit1; Sample Tissue: Rat Heart lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

RIT1 antibody

Western blot analysis on Jurkat cell lysate using RIT1 Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RIT1 antibody

Figure 1. Western blot analysis using Rit antibody (AM05290PU-N) on control 293 cells (Lane 1), 293 cells expressing HA-tagged Rit protein (LAne 2) and 293 cells expressing HA-tagged Rin protein (Lane 3). Mouse IgG1 14G7 Purified Hu, Ms WB
0.1 mg / €360.00
  Acris Antibodies GmbH

RIT1 antibody

RIT1 Rabbit IgG Purified Hu WB
0.1 mg / €360.00
  Acris Antibodies GmbH

RIT1 antibody

Western blot (WB) analysis of ROC1 antibody (Cat.-No.: AP06309PU-N) in extracts from A549 cells. Rabbit Aff - Purified Hu, Ms WB
0.1 mg / €350.00
  Acris Antibodies GmbH

RIT1 antibody

RIT1 polyclonal antibody (A01), Lot # 050914JC01 Western Blot analysis of RIT1 expression in HepG2 ( Cat # L019V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

RIT1 antibody

Western blot analysis using RIT1 monoclonal antibody, clone 14G7 ( Cat # MAB2011 ) on control 293 cells (lane 1), 293 cells expressing HA-tagged RIT1 protein (lane 2) and 293 cells expressing HA-tagged RIT2 protein (3). Hu, Ms
0.1 mg / €400.00
  Abnova Taiwan Corp.

RIT1 antibody

Western blot analysis of extracts from Jurkat cells, using RIT1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

RIT1 antibody

Western blot analysis of extracts from Jurkat cells, using RIT1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €310.00
  Assay Biotech

RIT1 (C-term) antibody

Human ACHN; WB Suggested Anti-RIT1 Antibody. . Titration: 1.0 ug/ml. . Positive Control: ACHN Whole Cell; RIT1 antibody - C-terminal region (ARP61779_P050) in Human ACHN cells using Western Blot Rabbit Aff - Purified Hu
50 µg / €350.00
  AVIVA Systems Biology

RIT1 (Center) antibody

Human THP-1; WB Suggested Anti-RIT1 Antibody. . Titration: 1.0 ug/ml. . Positive Control: THP-1 Whole Cell; RIT1 antibody - middle region (ARP61780_P050) in Human THP-1 cells using Western Blot Rabbit Aff - Purified Hu
50 µg / €350.00
  AVIVA Systems Biology

RIT1 antibody

Western blot analysis of RIT1 expression in A549 (A); HeLa (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Por, Rb, Sh WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

RIT1 antibody

Western blot analysis of RIT1 expression in A549 (A); HeLa (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Por, Rb, Sh WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

RIT1 antibody

Western blot analysis of RIT1 expression in A549 (A); HeLa (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Por, Rb, Sh WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

RIT1 antibody

RIT1 Mouse IgG1 14G7 Serum Hu, Ms WB
25 µg / €420.00
  Novus Biologicals Inc.

RIT1 antibody

RIT1 Rabbit IgG Aff - Purified Hu, Ms E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

RIT1 antibody

RIT1 Rabbit IgG Aff - Purified Hu, Ms E, WB
50 µg / €290.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RIT1

RIT1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

RIT1

RIT1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

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