RNASEH2A antibody

Principal name

RNASEH2A antibody

Alternative names for RNASEH2A antibody

Ribonuclease H2 subunit A, RNase H2 subunit A, RNAse H2A, RNase HI large subunit, RNASEHI, RNHIA, AGS4, Ribonuclease HI subunit A, Ribonuclease HI large subunit, Aicardi-Goutieres syndrome 4 protein

SwissProt ID

O75792 (Human), P53942 (Yeast), Q10236 (Schpo), Q2TBT5 (Bovin), Q5U209 (Rat), Q9CWY8 (Mouse), Q9SEZ6 (Arath), Q9U6P6 (Caeel), Q9VPP5 (Drome)

Gene ID

10535 (RNASEH2A), 69724 (Rnaseh2a), 364974

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Eq (Equine), Gt (Goat), Por (Porcine), Ye (Yeast)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of RNASEH2A antibody

Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.

General readings

Frank P., et al. (1998) Proc Natl Acad Sci USA. 95:12872-12877.Bayliss C D., et al. (2005) Nucleic Acads Res. 33:400-408.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RNASEH2A antibody

  Rabbit Polyclonal RNAse H2A Antibody  
Western blot analysis of RNAse H2A in HeLa cell lysate with RNAse H2A antibody at 1 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RNASEH2A antibody

  Rabbit Polyclonal Anti-RNASEH2A Antibody  
WB Suggested Anti-RNASEH2A Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysateRNASEH2A is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Hu P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

RNASEH2A antibody

  Rabbit Polyclonal Anti-RNASEH2A Antibody  
WB Suggested Anti-RNASEH2A Antibody Titration: 1.25 ug/ml; Positive Control: Jurkat cell lysateRNASEH2A is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, Eq, Gt, Hu, Ms, Por, Rt, Ye, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

RNASEH2A - human gene knockout kit via CRISPR

RNASEH2A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

RNASEH2A - human gene knockout kit via CRISPR

RNASEH2A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RNASEH2A - human gene knockout kit via CRISPR

RNASEH2A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RNASEH2A - human gene knockout kit via CRISPR

RNASEH2A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rnaseh2a - mouse gene knockout kit via CRISPR

Rnaseh2a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Rnaseh2a - mouse gene knockout kit via CRISPR

Rnaseh2a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rnaseh2a - mouse gene knockout kit via CRISPR

Rnaseh2a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rnaseh2a - mouse gene knockout kit via CRISPR

Rnaseh2a - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RNASEH2A

  Recombinant protein of human ribonuclease H2, subunit A (RNASEH2A)  
RNASEH2A Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

RNASEH2A (1-299, His-tag)

RNASEH2A Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €940.00
  Acris Antibodies GmbH

RNASEH2A (1-299, His-tag)

RNASEH2A Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

RNASEH2A overexpression lysate

RNASEH2A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Rnaseh2a (GFP-tagged) - Mouse ribonuclease H2, large subunit (cDNA clone MGC:36700 IMAGE:3666709), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rnaseh2a (GFP-tagged) - Mouse ribonuclease H2, large subunit (cDNA clone MGC:36700 IMAGE:3666709), 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rnaseh2a (GFP-tagged) - Mouse ribonuclease H2, large subunit (Rnaseh2a), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rnaseh2a (GFP-tagged) - Mouse ribonuclease H2, large subunit (Rnaseh2a), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rnaseh2a (Myc-DDK-tagged) - Mouse ribonuclease H2, large subunit (cDNA clone MGC:36700 IMAGE:3666709), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rnaseh2a (Myc-DDK-tagged) - Mouse ribonuclease H2, large subunit (cDNA clone MGC:36700 IMAGE:3666709), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, Rnaseh2a (Myc-DDK-tagged) - Mouse ribonuclease H2, large subunit (Rnaseh2a), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rnaseh2a (Myc-DDK-tagged) - Mouse ribonuclease H2, large subunit (Rnaseh2a), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Rnaseh2a (GFP-tagged ORF) - Rat ribonuclease H2, subunit A (Rnaseh2a), 200 uL, >10^7 TU/mL

Lenti ORF particles, Rnaseh2a (GFP-tagged ORF) - Rat ribonuclease H2, subunit A (Rnaseh2a), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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