ROR-alpha / RORA antibody

Principal name

ROR-alpha / RORA antibody

Alternative names for ROR-alpha / RORA antibody

Nuclear receptor ROR-alpha, Nuclear receptor RZR-alpha, NR1F1, RZRA, Nuclear receptor subfamily 1 group F member 1, Retinoid-related orphan receptor-alpha

SwissProt ID

P35398 (Human), P51448 (Mouse)

Gene ID

6095 (RORA), 19883 (Rora)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Gt (Goat), Por (Porcine), Rb (Rabbit), Sh (Sheep), Xen (Xenopus)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of ROR-alpha / RORA antibody

Retinoid-related orphan receptor alpha (ROR alpha), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the staggerer phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Four isoforms that differ in the N-terminal regions have been isolated, and their spatiotemporal expression appears to be under isoform-specific regulation. ROR alpha isoforms have the same DNA-binding domain but display different DNA binding specificities. ROR alpha 1 binds to and constitutively activates transcription from a large subset of ROR elements, while ROR alpha 2 recognizes ROR elements with strict specificity and displays weaker transcriptional activity. The N-terminal domain and zinc-finger region work in concert to confer high affinity and specific DNA-binding properties to the ROR isoforms and suggest a novel strategy for the control of DNA-binding activities of nuclear receptors. It has been suggested that melatonin may affect ROR alpha transcriptional activity and expression of ROR alpha-regulated genes via modulation of the Ca(2+)/CaM signaling pathway. The structure of the ligand-binding domain (LBD) of ROR alpha and a potential natural ligand have been elucidated recently.
ROR alpha expression has been documented in human adipose, brain, breast, heart. liver, lung, muscle, ovary, PBLs, prostate, small intestine, spleen and testis.
ESTs have been isolated from cancerous human tissues including lung, tongue, skeletal muscle, and germ cell, and from human normal tissues including liver/spleen, testis, brain, and skin. Ligand: Cholesterol has been suggested as a putative ligand.

General readings

Miki,N., et al., (2004) J. Biol. Chem. 279 (15), 15025-15031

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

ROR Common antibody

ROR Mouse IgG2a H3925 Purified Hu, Rt ELISA, IP, P
0.1 ml / €640.00
  Funakoshi Co., Ltd.

ROR-alpha / RORA antibody

Western blot analysis of extracts from HeLa cells and COS-7 cells, using RORA antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

Western blot analysis of anti-RORA Antibody (T216) (Cat.#TA324372) in A2058 cell line lysates (35ug/lane). RORA (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

Hela (1) and HepG2 (2) cell nuclear extract were resolved by electrophoresis, transferred to nitrocellulose, and probed with purified anti-RORa antibody. Proteins were visualized using donkey anti-rabbit secondary conjugated to HRP and a chemiluminescence detection system. Rabbit IgG Poly6388 Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

WB Suggested Anti-RORA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: MCF7 cell lysate Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

WB Suggested Anti-RORA Antibody Titration: 4.0ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

Host: Rabbit; Target Name: Rora; Sample Tissue: Mouse Liver lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

Host:Rabbit; Target Name:RORA; Sample Tissue:Human Adult Placenta; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

WB Suggested Anti-RORA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Lung Rabbit IgG Purified Bov, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

WB Suggested Anti-RORA Antibody Titration: 1.25 ug/ml; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Rb, Rt, Sh, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

WB Suggested Anti-RORA Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

WB Suggested Anti-RORA Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

ROR-alpha / RORA (Hinge Dom.) antibody

Anti-ROR Alpha / RORA antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 11-17 ug/ml. Rabbit Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Eq, Fi, Hst, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rb, Rt, Tr, Xen P
50 µg / €379.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

Anti-RORA / ROR Alpha antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

ROR-alpha / RORA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RORA (RC214618, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RORA. Mouse IgG2a OTI2E8 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ROR-alpha / RORA antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RORA (RC214618, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RORA. Mouse IgG2b OTI2C4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

ROR-alpha / RORA antibody

Immunohistochemistry analyzes of RORα antibody (Cat.-No.: AP20414PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

ROR-alpha / RORA antibody

ROR-alpha / RORA Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

ROR-alpha / RORA antibody

Western Blot analysis of RORA expression in transfected 293T cell line (H00006095-T02) by RORA MaxPab polyclonal antibody.

Lane 1: RORA transfected lysate(53.50 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

ROR-alpha / RORA antibody

Detection limit for recombinant GST tagged RORA is approximately 0.3ng/ml as a capture antibody. Mouse IgG 4E3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

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