RP1 / ORP1 antibody

Principal name

RP1 / ORP1 antibody

Alternative names for RP1 / ORP1 antibody

Retinitis pigmentosa 1 protein, Retinitis pigmentosa RP1 protein, Oxygen-regulated protein 1

Gene ID

6101 (RP1)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts


Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of RP1 / ORP1 antibody

Retinitis pigmentosa 1 (RP1), also known as oxygen-regulated protein 1, retinitis pigmentosa 1 protein, ORP1, and DCDC4A, regulates the stability and length of microtubule based axoneme of photoreceptors. RP1 is critical for the differentiation of photoreceptor cells, and RP1 also influences the photosensitivity and outer segment morphogenesis of rod photoreceptors. Similarly, RP1 controls the correct orientation and higher order stacking of the outer segment disks along the photoreceptor axoneme. RP1 is found in the cytoplasm and has only been reported in the reti. RP1 is subject to phosphorylation, and mutations in RP1 cause autosomal recessive and domint retinitis pigmentosa. Both of these diseases lead to degeneration of the retil photoreceptor cells resulting in night blindness, loss of peripheral visual field, and eventually loss of central vision (PMID: 10391211).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RP1 / ORP1 antibody

Immunohistochemistry: RP1 Antibody [TA336927] - IHC analysis of RP1 in mouse retina. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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