RPS6KB1 / STK14A antibody

Principal name

RPS6KB1 / STK14A antibody

Alternative names for RPS6KB1 / STK14A antibody

Ribosomal protein S6 kinase I, S6K1, p70 S6 kinase alpha, p70 S6K-alpha, p70 S6KA, Serine/threonine-protein kinase 14A, Ribosomal protein S6 kinase beta-1, S6K-beta-1, 70 kDa ribosomal protein S6 kinase 1, 70 kDa ribosomal protein S6 kinase 1, p70-S6K 1

SwissProt ID

P23443 (Human), P67998 (Rabit), P67999 (Rat), Q6TJY3 (Bovin), Q8BSK8 (Mouse)

Gene ID

6198 (RPS6KB1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Por (Porcine), Rb (Rabbit), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), ELISA (detection) (E(detection)), Frozen Sections (C), Flow Cytometry (F)

Background of RPS6KB1 / STK14A antibody

Acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling; probably phosphorylates RICTOR at 'Thr-1135'. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance; probably phosphorylates IRS1 at 'Ser-270'. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD at 'Ser-99' in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex; probably phosphorylates RMP at 'Ser-99'. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates GSK3B at 'Ser-9' under conditions leading to loss of the TSC1-TSC2 complex. Phosphorylates POLDIP3.

General readings

Grove JR et al. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol Cell Biol 11:5541-50 (1991). PubMed PMID: 1922062

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RPS6KB1/RPS6KB2 antibody

RPS6KB1/RPS6KB2 Rabbit Hu, Ms, Rt E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

RPS6KB1 / STK14A antibody

Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-RPS6KB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502929) Mouse IgG1 OTI6B2 Purified Can, Hu, Mky, Ms ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

RPS6KB1 / STK14A (Center) antibody

Western blot analysis of anti-RPS6KB1 Antibody (Center) Pab (Cat.#TA302199) in Jurkat cell line lysates (35ug/lane). RPS6KB1 Antibody (Center))(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RPS6KB1 / STK14A antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-RPS6KB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502913) Mouse IgG1 OTI1G4 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

RPS6KB1 / STK14A antibody

Immunohistochemical analysis of paraffin-embedded breast cancer tissues (left) and muscle tissues (right) using RPS6KB1 antibody Cat.-No AM06724PU-N with DAB staining. Mouse IgG1 5G9 Purified Hu E, F, P, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A pSer424 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase antibody (AP02525PU-S; AP02525PU-N). Rabbit Aff - Purified Hu, Ms P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A pSer424 antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase antibody (AP02525PU-S; AP02525PU-N). Rabbit Aff - Purified Hu, Ms P, WB
50 µl / €240.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A antibody

Immunoperoxidase of monoclonal antibody to RPS6KB1 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 0.5 ug/ml] Mouse IgG2b 1E12 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

RPS6KB1 / STK14A antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between STK11 and RPS6KB1 HeLa cells were stained with anti-STK11 rabbit purified polyclonal 1:1200 and anti-RPS6KB1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG 1E10 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

RPS6KB1 / STK14A antibody

Immunofluorescence of monoclonal antibody to RPS6KB1 on A-431 cell. [antibody concentration 10 ug/ml] Mouse IgG1 2C2 Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

RPS6KB1 / STK14A antibody

Immunofluorescence of monoclonal antibody to RPS6KB1 on HeLa cell. [antibody concentration 10 ug/ml] Mouse IgG 4H4 Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

RPS6KB1 / STK14A non pThr421/pSer424 antibody

Human breast carcinoma stained with anti-p70S6K (Paired421/424) antibody Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A non pThr421/pSer424 antibody

Human breast carcinoma stained with anti-p70S6K (Paired421/424) antibody Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A non pThr421/pSer424 antibody

Human breast carcinoma stained with anti-p70S6K (Paired421/424) antibody Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A (C-term) antibody

TA302669 staining (0.05µg/ml) of Human Placenta lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P, WB
20 µg / €200.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A antibody

AP23804PU p70S6k antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A antibody

AP23804PU p70S6k antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A pThr421/pSer424 antibody

AP23804PU p70S6k antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

RPS6KB1 / STK14A antibody

Western blot analysis of RPS6KB1 (arrow) using rabbit polyclonal RPS6KB1 Antibody (S424) (RB11404). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RPS6KB1 gene (Lane 2) (Origene Technologies). Rabbit Ig Aff - Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RPS6KB1 / STK14A antibody

Western blot analysis of RPS6KB1 (arrow) using rabbit polyclonal RPS6KB1 Antibody (S404) (RB11396). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the RPS6KB1 gene (Lane 2) (Origene Technologies). Rabbit Ig Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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