RRM2 / RR2 antibody

Principal name

RRM2 / RR2 antibody

Alternative names for RRM2 / RR2 antibody

Ribonucleotide reductase small subunit, Ribonucleotide reductase small chain, Ribonucleoside-diphosphate reductase subunit M2

SwissProt ID

P11157 (Mouse), P31350 (Human), P36603 (Schpo), P42170 (Caeel), P48592 (Drome), P79733 (Danre), Q4KLN6 (Rat)

Gene ID

6241 (RRM2), 4307339 (Q0BKJ6)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Por (Porcine), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Xen (Xenopus), Eq (Equine), GP (Guinea Pig)

Available hosts

Mouse, Chicken, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunoprecipitation (IP)

Background of RRM2 / RR2 antibody

Ribonucleotide reductase is essential for the production and maintenance of the level of deoxyribonucleoside triphosphates (dNTPs) required for DNA synthesis. It is an enzymatic complex consisting of two nonidentical subunits, R1 and R2, which are inactive separately. R2, the smaller subunit, is localized to the cytoplasm. R2 is the limiting factor of the catalytic activity of the ribonucleotide reductase enzymatic complex. R2 expression is strictly correlated to the S-phase of the cell cycle, whereas R1 remains constant throughout all phases of the cell cycle. While R2 seems to be involved solely in the maintenance of dNTPs for DNA replication, a similar protein, p53R2, has been shown to be responsible for the production of dNTPs in response to DNA damage.

General readings

1. Qiu,W., Zhou,B., Darwish,D., Shao,J. and Yen,Y., et al. Characterization of enzymatic properties of human ribonucleotide reductase holoenzyme reconstituted in vitro from hRRM1, hRRM2, and p53R2 subunits
2. Lin,Z.P., Belcourt,M.F., Cory,J.G. and Sartorelli,A.C., et al. Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors
3. Duxbury,M.S., Ito,H., Zinner,M.J., Ashley,S.W. and Whang,E.E., et al. RNA interference targeting the M2 subunit of ribonucleotide reductase enhances pancreatic adenocarcinoma chemosensitivity to gemcitabine
4. Shao,J., Zhou,B., Zhu,L., Qiu,W., Yuan,Y.C., Xi,B. and Yen,Y., et al. In vitro characterization of enzymatic properties and inhibition of the p53R2 subunit of human ribonucleotide reductase
5. Zhou,B., Liu,X., Mo,X., Xue,L., Darwish,D., Qiu,W., Shih,J., Hwu,E.B., Luh,F. and Yen,Y. The human ribonucleotide reductase subunit hRRM2 complements p53R2 in response to UV-induced DNA repair in cells with mutant p53
6. , Pavloff N., Rivard D., Masson S., Shen S.-H., Mes-Masson A.-M. Sequence analysis of the large and small subunits of human ribonucleotide reductase.
7. , Zhou B., Yen Y. Characterization of the human ribonucleotide reductase M2 subunit gene
genomic structure and promoter analyses.
8. , Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., et al. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
9. , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RRM2 / RR2 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 1E1 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

RRM2 / RR2 antibody

Immunoperoxidase of monoclonal antibody to RRM2 on formalin-fixed paraffin-embedded human stomach. [antibody concentration 1.5 ug/ml] Mouse IgG1 1E1 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

RRM2 / RR2 antibody

Western blot analysis of extracts of various cell lines, using RRM2 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

RRM2 / RR2 antibody

WB Suggested Anti-RRM2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Muscle Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

RRM2 / RR2 (Center) antibody

Western blot analysis of RRM2 antibody (Center) (AP17721PU-N) in Jurkat cell line lysates (35ug/lane). RRM2 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

RRM2 / RR2 antibody

RRM2 / RR2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

RRM2 / RR2 antibody

Immunofluorescence of purified MaxPab antibody to RRM2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Serum Hu E(detection), ICC/IF, WB
50 µl / €370.00
  Abnova Taiwan Corp.

RRM2 / RR2 antibody

Immunoprecipitation of RRM2 transfected lysate using anti-RRM2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with RRM2 MaxPab mouse polyclonal antibody (B01) (H00006241-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

RRM2 / RR2 antibody

Western Blot analysis of RRM2 expression in transfected 293T cell line (H00006241-T01) by RRM2 MaxPab polyclonal antibody.

Lane 1: RRM2 transfected lysate(44.90 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

RRM2 / RR2 antibody

RRM2 / RR2 Mouse IgG1 1E1 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

RRM2 / RR2 antibody

Human Muscle; WB Suggested Anti-RRM2 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Muscle; RRM2 antibody - N-terminal region (ARP46031_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Por WB
50 µg / €350.00
  AVIVA Systems Biology

RRM2 / RR2 antibody

RRM2 / RR2 Rabbit Aff - Purified Hu, Ms, Rt, Xen WB
0.1 mg / €510.00
  Funakoshi Co., Ltd.

RRM2 / RR2 antibody

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-RRM2 ) Chicken Aff - Purified Hu WB
50 µg / €520.00
  Novus Biologicals Inc.

RRM2 / RR2 antibody

Immunohistochemistry-Paraffin: RRM2 Antibody [NBP1-31661] - Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using RRM2(NBP1-31661) antibody at 1:500 dilution. Rabbit IgG Hu ICC/IF, P, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

RRM2 / RR2 antibody

Western Blot: RRM2 Antibody [NBP1-58189] - This Anti-RRM2 antibody was used in Western Blot of Fetal Muscle   tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RRM2 / RR2

RRM2 / RR2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

RRM2 / RR2 (1-389, His-tag)

RRM2 / RR2 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €670.00
  Acris Antibodies GmbH

RRM2 / RR2 (1-389, His-tag)

RRM2 / RR2 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €250.00
  Acris Antibodies GmbH

RRM2 / RR2

RRM2 / RR2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

RRM2 / RR2

RRM2 / RR2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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