RRM2B / P53R2 antibody

Principal name

RRM2B / P53R2 antibody

Alternative names for RRM2B / P53R2 antibody

Ribonucleoside-diphosphate reductase subunit M2 B, TP53-inducible ribonucleotide reductase M2 B, p53-inducible ribonucleotide reductase small subunit 2-like protein

SwissProt ID

Q6PEE3 (Mouse), Q6Y657 (Arath), Q7LG56 (Human), Q9NTD8 (Human)

Gene ID

50484 (RRM2B), 382985 (Rrm2b)

Available reactivities

Hu (Human), Eq (Equine), Mky (Monkey), Ms (Mouse), Prim (Primate), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of RRM2B / P53R2 antibody

RRM2B/p53-R2, or p53-inducible ribonucleotide reductase small subunit 2-like protein, is a member of a broad superfamily of ferritin-like di-ironcarboxylate proteins. The RRM2B protein is an enzyme that catalyzes the conversion of ribonucleotides to deoxyribonucleotides that are essential for DNA synthesis, and is found in all eukaryotes. RRM2B plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. It supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. It contains an iron-tyrosyl free radical center required for catalysis, and forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. It is a heterotetramer with a large (RRM1) subunit, and interacts with p53/TP53. The interaction with RRM1 occurs in response to DNA damage and results in its translocation from cytoplasm to nucleus. It is widely expressed at a high level in skeletal muscle and at a weak level in thymus, and expressed in epithelial dysplasias and squamous cell carcinoma. Defects in RRM2B are the cause of encephalomyopathic mitochondrial depletion syndrome with renal tubulopathy (EMDSRT). Mitochondrial DNA depletion syndrome (MDS) is a clinically heterogeneous group of disorders characterized by a reduction in mitochondrial DNA (mtDNA) copy number. The encephalomyopathic form with renal tubulopathy is presented with various combinations of hypotonia, tubulopathy, seizures, respiratory distress, diarrhea, and lactic acidosis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RRM2B / P53R2 (N-term) antibody

  Rabbit Polyclonal p53R2 Antibody  
Immunofluorescence of p53R2 in Human Lung tissue with p53R2 antibody at 20 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RRM2B / P53R2 antibody

  Rabbit polyclonal anti-RRM2B antibody  
Western blot analysis of extracts from COLO205 cells, using RRM2B antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RRM2B / P53R2 antibody

  Rabbit polyclonal RRM2B p53R2 antibody  
WB using Anti-RRM2B antibody shows detection of recombinant (lanes 1 and 3) and endogenous protein (lanes 1 to 4) in whole cell extracts from transfected 293T. Lane 1 contains purified recombinant human p53R2. Lane 2 contains 293T cells transfected with control vector. Lane 3 contains 293T transfected with p53R2-myc. Lane 4: 293T transfected with ScRNA. Lane 5: 293T tranfected with p53R2 SiRNA. Primary antibody was diluted to 1µg/mL and incubated overnight at 4?. Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

RRM2B / P53R2 (2-17) antibody

Figure 2. Formalin-Fixed Paraffin-Embedded (FFPE) on Brain, cerebellum. Rabbit Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

RRM2B - human gene knockout kit via CRISPR

RRM2B - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

RRM2B - human gene knockout kit via CRISPR

RRM2B - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RRM2B - human gene knockout kit via CRISPR

RRM2B - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RRM2B - human gene knockout kit via CRISPR

RRM2B - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rrm2b - mouse gene knockout kit via CRISPR

Rrm2b - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Rrm2b - mouse gene knockout kit via CRISPR

Rrm2b - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rrm2b - mouse gene knockout kit via CRISPR

Rrm2b - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Rrm2b - mouse gene knockout kit via CRISPR

Rrm2b - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RRM2B / P53R2

  Recombinant protein of human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B)  
RRM2B / P53R2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

RRM2B overexpression lysate

RRM2B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

RRM2B overexpression lysate

RRM2B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

RRM2B-knockout Cell lysate

RRM2B-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, RRM2B (mGFP-tagged) - Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, RRM2B (mGFP-tagged) - Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, RRM2B (mGFP-tagged) - Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, RRM2B (mGFP-tagged) - Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,020.00
  OriGene Technologies, Inc.

Lenti ORF particles, RRM2B (mGFP-tagged) - Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, RRM2B (mGFP-tagged) - Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, RRM2B (Myc-DDK tagged) - Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, RRM2B (Myc-DDK tagged) - Human ribonucleotide reductase M2 B (TP53 inducible) (RRM2B), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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