RRP4 / EXOSC2 antibody

Principal name

RRP4 / EXOSC2 antibody

Alternative names for RRP4 / EXOSC2 antibody

Exosome component 2, Exosome complex exonuclease RRP4, Ribosomal RNA-processing protein 4

SwissProt ID

Q13868 (Human), Q2KID0 (Bovin), Q8VBV3 (Mouse)

Gene ID

23404 (EXOSC2), 227715 (Exosc2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Chk (Chicken), Ze (Zebrafish), African clawed frog, Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of RRP4 / EXOSC2 antibody

Non-catalytic component of the R exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular R processing and degradation events. In the nucleus, the R exosome complex is involved in proper maturation of stable R species such as rR, snR and snoR, in the elimition of R processing by-products and non-coding 'pervasive' transcripts, such as antisense R species and promoter-upstream transcripts (PROMPTs), and of mRs with processing defects, thereby limiting or excluding their export to the cytoplasm. The R exosome may be involved in Ig class switch recombition (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamition activity to transcribed dsD substrates. In the cytoplasm, the R exosome complex is involved in general mR turnover and specifically degrades inherently unstable mRs containing AU-rich elements (AREs) within their 3' untranslated regions, and in R surveillance pathways, preventing translation of aberrant mRs. It seems to be involved in degradation of histone mR. The catalytic ictive R exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of R for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC2 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of Rse PH-domain subunits through contacts with EXOSC4 and EXOSC7.

General readings

Beausoleil,S.A., (2004) Proc. Natl. Acad. Sci. U.S.A. 101 (33), 12130-12135

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RRP4 / EXOSC2 antibody

  Rabbit polyclonal anti-EXOSC2 antibody(N-term)  
EXOSC2 Antibody(N-term) (Cat. #TA328143) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the EXOSC2 antibody detected the EXOSC2 protein (arrow). Rabbit Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

RRP4 / EXOSC2 antibody

  Rabbit Polyclonal Anti-EXOSC2 Antibody  
WB Suggested Anti-EXOSC2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

RRP4 / EXOSC2 antibody

  Rabbit Polyclonal Anti-EXOSC2 Antibody  
WB Suggested Anti-EXOSC2 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Jurkat cell lysateEXOSC2 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RRP4 / EXOSC2 antibody

RRP4 / EXOSC2 Mouse IgG1 15B3 Purified Hu E
0.1 mg / €810.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

EXOSC2 - human gene knockout kit via CRISPR

EXOSC2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

EXOSC2 - human gene knockout kit via CRISPR

EXOSC2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

EXOSC2 - human gene knockout kit via CRISPR

EXOSC2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

EXOSC2 - human gene knockout kit via CRISPR

EXOSC2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Exosc2 - mouse gene knockout kit via CRISPR

Exosc2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Exosc2 - mouse gene knockout kit via CRISPR

Exosc2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Exosc2 - mouse gene knockout kit via CRISPR

Exosc2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Exosc2 - mouse gene knockout kit via CRISPR

Exosc2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RRP4 / EXOSC2

  Recombinant protein of human exosome component 2 (EXOSC2)  
RRP4 / EXOSC2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

EXOSC2 overexpression lysate

EXOSC2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, EXOSC2 (mGFP-tagged) - Human exosome component 2 (EXOSC2), 200 uL, >10^7 TU/mL

Lenti ORF particles, EXOSC2 (mGFP-tagged) - Human exosome component 2 (EXOSC2), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, EXOSC2 (Myc-DDK tagged) - Human exosome component 2 (EXOSC2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, EXOSC2 (Myc-DDK tagged) - Human exosome component 2 (EXOSC2) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Exosc2 (GFP-tagged) - Mouse exosome component 2 (Exosc2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Exosc2 (GFP-tagged) - Mouse exosome component 2 (Exosc2), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Exosc2 (Myc-DDK-tagged) - Mouse exosome component 2 (Exosc2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Exosc2 (Myc-DDK-tagged) - Mouse exosome component 2 (Exosc2), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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