RTEL1 antibody

Principal name

RTEL1 antibody

Alternative names for RTEL1 antibody

C20orf41, KIAA1088, NHL, Novel helicase-like, Regulator of telomere elongation helicase 1

SwissProt ID

P0C928 (Danre), Q9BW37 (Human), Q9NZ71 (Human)

Gene ID

51750 (RTEL1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of RTEL1 antibody

RTEL1 (Regulator of Telomere Length 1) is a nuclear iron-sulfur cluster containing ATP-dependent D helicase essential to genomic stability. RTEL1 contains 1 helicase ATP-binding domain and it belongs to helicase family, RAD3/XPD subfamily. Origilly discovered in mouse, RTEL1 is a domint factor controlling the regulation of telomeric length and genomic integrity, and recent evidence suggest that RTEL1 is preferentially recruited to, or exerts greater activity at genome's G-rich regions. In D double-strand breaks (DSBs) repair, RTEL1 disrupts D-loops in vitro and promotes synthesis-dependent strand annealing (SDSA) in vivo to direct D DSBs into non-crossover outcomes during mitotic repair. RTEL1 activity is also essential to meiotic recombition regulation as shown in C elegans. RTEL1's multiple roles in genomic stability maintence and recombition regulation suggests it as a tumor suppressor. Indeed, RTEL1 mutation represents a risk factor for glioma and it is overexpressed in gastrointestil cancers. Human RTEL1 deficiency caused Hoyeraal-Hreidarsson syndrome (HHS), a severe variant of Dyskeratosis Congenita (DC), characterized by early onset bone marrow failure, immunodeficiency and developmental defects.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RTEL1 antibody

Western Blot: RTEL1 Antibody [TA336935] - WB analysis of RTEL1 in HeLa cell lysate. Rabbit Purified Hu, Ms C, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RTEL1 (N-term) antibody

Anti-RTEL1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

RTEL1 antibody

RTEL1 Rabbit Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

RTEL1 antibody

RTEL1 Rabbit Hu, Ms E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

RTEL1 antibody

RTEL1 Rabbit Hu, Ms E, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

RTEL1 overexpression lysate

RTEL1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

6 Item(s)

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