RTEL1 antibody

Principal name

RTEL1 antibody

Alternative names for RTEL1 antibody

C20orf41, KIAA1088, NHL, Novel helicase-like, Regulator of telomere elongation helicase 1

SwissProt ID

P0C928 (Danre), Q9BW37 (Human), Q9NZ71 (Human)

Gene ID

51750 (RTEL1)

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of RTEL1 antibody

RTEL1 (Regulator of Telomere Length 1) is a nuclear iron-sulfur cluster containing ATP-dependent D helicase essential to genomic stability. RTEL1 contains 1 helicase ATP-binding domain and it belongs to helicase family, RAD3/XPD subfamily. Origilly discovered in mouse, RTEL1 is a domint factor controlling the regulation of telomeric length and genomic integrity, and recent evidence suggest that RTEL1 is preferentially recruited to, or exerts greater activity at genome's G-rich regions. In D double-strand breaks (DSBs) repair, RTEL1 disrupts D-loops in vitro and promotes synthesis-dependent strand annealing (SDSA) in vivo to direct D DSBs into non-crossover outcomes during mitotic repair. RTEL1 activity is also essential to meiotic recombition regulation as shown in C elegans. RTEL1's multiple roles in genomic stability maintence and recombition regulation suggests it as a tumor suppressor. Indeed, RTEL1 mutation represents a risk factor for glioma and it is overexpressed in gastrointestil cancers. Human RTEL1 deficiency caused Hoyeraal-Hreidarsson syndrome (HHS), a severe variant of Dyskeratosis Congenita (DC), characterized by early onset bone marrow failure, immunodeficiency and developmental defects.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RTEL1 antibody

  Rabbit Polyclonal RTEL1 Antibody  
Western Blot: RTEL1 Antibody [TA336935] - WB analysis of RTEL1 in HeLa cell lysate. Rabbit Purified Hu, Ms C, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

RTEL1 (N-term) antibody

  RTEL1 Rabbit Polyclonal (N-Terminus) Antibody  
Anti-RTEL1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

RTEL1 - human gene knockout kit via CRISPR

RTEL1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

RTEL1 - human gene knockout kit via CRISPR

RTEL1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RTEL1 - human gene knockout kit via CRISPR

RTEL1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RTEL1 - human gene knockout kit via CRISPR

RTEL1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

RTEL1 overexpression lysate

RTEL1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, RTEL1 (mGFP-tagged)-Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, RTEL1 (mGFP-tagged)-Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,390.00
  OriGene Technologies, Inc.

Lenti ORF particles, RTEL1 (mGFP-tagged) - Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, RTEL1 (mGFP-tagged) - Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €2,510.00
  OriGene Technologies, Inc.

Lenti ORF particles, RTEL1 (Myc-DDK-tagged)-Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, RTEL1 (Myc-DDK-tagged)-Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, RTEL1 (Myc-DDK tagged) - Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, RTEL1 (Myc-DDK tagged) - Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €2,270.00
  OriGene Technologies, Inc.

11 Item(s)

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