RUNX1 antibody

Principal name

RUNX1 antibody

Alternative names for RUNX1 antibody

Runt-related transcription factor, 1, AML1, AML-1, AMLCR1, Acute myeloid leukemia 1 protein, AML1-EVI-1, EVI-1, CBFA2, CBF-alpha-2, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Core-binding factor subunit alpha-2, Polyomavirus enhancer-binding protein 2 alpha B subunit, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit

SwissProt ID

Q01196 (Human), Q03347 (Mouse), Q16284 (Human), Q63046 (Rat), Q6PF39 (Xenla)

Gene ID

861 (RUNX1), 12394 (Runx1), 50662

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of RUNX1 antibody

RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. RUNX1 was first identified as a RUNX1-ETO fusion protein in acute myeloid leukaemia (AML) and is frequently mutated in AML and myelodysplastic syndrome due to chromosomal translocation. RUNX1-deficient mice fail to generate hematopoietic stem cells. RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. Impaired differentiation of megakaryocytes and decreased circulating platelet count was observed in the absence of RUNX1. These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages.

General readings

Ghozi,M.C., et al., (1996) Proc. Natl. Acad. Sci. U.S.A. 93 (5), 1935-1940

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RUNX1 (210-311) antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 4E7 Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €420.00
  OriGene Technologies GmbH

RUNX1 antibody

  Rabbit Polyclonal RUNX1 Antibody  
Western blot analysis of RUNX1 in Raji cell lysate with RUNX1 antibody at (A) 1 and (B) 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €371.00
  OriGene Technologies, Inc.

RUNX1 antibody

  Rabbit polyclonal AML1 / RUNX1 (Ab-435) antibody  
Western blot analysis of extracts from HepG2 cells, treated with PMA (125ng/ml, 30mins), using AML1 (Ab-435) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

RUNX1 antibody

  Rabbit polyclonal AML1 / RUNX1 (Ser435) antibody(Phospho-specific)  
Western blot analysis of extracts from HepG2 cells, treated with PMA (125ng/ml, 30mins), using AML1 (Phospho-Ser435) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

RUNX1 antibody

  Anti-CBFA2 Rabbit Polyclonal Antibody  
Predicted band size: 26kDa. Positive control: Human urinary bladder tissue lysate . Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

RUNX1 antibody

  Anti-RUNX1 Rabbit Polyclonal Antibody  
Predicted band size: 51 kDa . Positive control: SH-SY5Y cell, mouse liver and spleen tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lane1: SH-SY5Y cell lysate Lane2: Mouse liver tissue lysate Lane3: Mouse spleen tissue lysate Lysates: 40 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

RUNX1 antibody

  Rabbit Polyclonal AML1 Antibody  
Western blot analysis of AML1 expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

RUNX1 antibody

  Rabbit Polyclonal AML1 (Ser276) Antibody (Phospho-specific)  
Western blot analysis of AML1 phosphorylation expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

RUNX1 antibody

  Rabbit Polyclonal AML1 (Ser303) Antibody (Phospho-specific)  
Western blot analysis of AML1 phosphorylation expression in Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

RUNX1 antibody

  RUNX1 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using RUNX1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €335.00
  OriGene Technologies, Inc.

RUNX1 antibody

  Rabbit Polyclonal RUNX1/CBFA2 Antibody  
Western Blot: RUNX1 Antibody [TA336280] - Analysis of AML-1 in (A) human Ramosand (B) mouse Raw cell lysate using this antibody at 5 ug/ml. Rabbit Purified Hu, Ms WB
0.1 mg / €393.00
  OriGene Technologies, Inc.

RUNX1 antibody

Immunohistochemistry (IHC) analyzes of AML1 antibody (Cat.-No.: AP06369PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

RUNX1 antibody

Immunohistochemistry analyzes of AML1 antibody (AP20291PU-N) in paraffin-embedded human lung carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  OriGene Technologies GmbH

RUNX1 pSer435 antibody

Western blot analysis of extracts from 293 cells (Lane 2), HeLa cells (Lane 3) and HepG2 cells (Lane 4), using AML1 (Phospho-Ser435) Antibody AP55801PU-N. The lane on the left is treated with antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
  OriGene Technologies GmbH

RUNX1 pSer435 antibody

Western blot analysis of extracts from 293 cells (Lane 2), HeLa cells (Lane 3) and HepG2 cells (Lane 4), using AML1 (Phospho-Ser435) Antibody AP55801PU-N. The lane on the left is treated with antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €270.00
  OriGene Technologies GmbH

RUNX1 pSer276 antibody

Western blot analysis of extracts from Jurkat cells, using AML1 (Phospho-Ser276) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

RUNX1 pSer276 antibody

Western blot analysis of extracts from Jurkat cells, using AML1 (Phospho-Ser276) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

RUNX1 pSer303 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using AML1 (Phospho-Ser303) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

RUNX1 pSer303 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using AML1 (Phospho-Ser303) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

RUNX1 pSer435 antibody

Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 30', using AML1 (Phospho-Ser435) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

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