RUNX1 antibody

Principal name

RUNX1 antibody

Alternative names for RUNX1 antibody

Runt-related transcription factor, 1, AML1, AML-1, AMLCR1, Acute myeloid leukemia 1 protein, AML1-EVI-1, EVI-1, CBFA2, CBF-alpha-2, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Core-binding factor subunit alpha-2, Polyomavirus enhancer-binding protein 2 alpha B subunit, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit

SwissProt ID

Q01196 (Human), Q03347 (Mouse), Q16284 (Human), Q63046 (Rat), Q6PF39 (Xenla)

Gene ID

861 (RUNX1), 12394 (Runx1), 50662

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of RUNX1 antibody

RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. RUNX1 was first identified as a RUNX1-ETO fusion protein in acute myeloid leukaemia (AML) and is frequently mutated in AML and myelodysplastic syndrome due to chromosomal translocation. RUNX1-deficient mice fail to generate hematopoietic stem cells. RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. Impaired differentiation of megakaryocytes and decreased circulating platelet count was observed in the absence of RUNX1. These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages.

General readings

Ghozi,M.C., et al., (1996) Proc. Natl. Acad. Sci. U.S.A. 93 (5), 1935-1940

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RUNX1 antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 2C10 Purified Hu E, ICC/IF, P, WB
50 µg / €420.00
  OriGene Technologies GmbH

RUNX1 (210-311) antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 4E7 Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €420.00
  OriGene Technologies GmbH

RUNX1 antibody

Immunofluorescence analysis of Hela cells using RUNX1 antibody Cat.-No AM06583SU-N (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Mouse IgG1 5A1 Ascites Hu E, ICC/IF, WB
0.1 ml / €430.00
  OriGene Technologies GmbH

RUNX1 antibody

Western blot analysis using RUNX1 antibody Cat.-No AM06605SU-N against Jurkat cell lysate. Mouse IgG1 2B5 Ascites Hu E, WB
0.1 ml / €430.00
  OriGene Technologies GmbH

RUNX1 antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 3A1 Purified Hu E, ICC/IF, P, WB
50 µg / €420.00
  OriGene Technologies GmbH

RUNX1 antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 3A8 Purified Hu E, ICC/IF, P
50 µg / €420.00
  OriGene Technologies GmbH

6 Item(s)

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