RUNX1 antibody

Principal name

RUNX1 antibody

Alternative names for RUNX1 antibody

Runt-related transcription factor, 1, AML1, AML-1, AMLCR1, Acute myeloid leukemia 1 protein, AML1-EVI-1, EVI-1, CBFA2, CBF-alpha-2, PEA2-alpha B, PEBP2-alpha B, PEBP2A2, Core-binding factor subunit alpha-2, Polyomavirus enhancer-binding protein 2 alpha B subunit, SL3-3 enhancer factor 1 alpha B subunit, SL3/AKV core-binding factor alpha B subunit

SwissProt ID

Q01196 (Human), Q03347 (Mouse), Q16284 (Human), Q63046 (Rat), Q6PF39 (Xenla)

Gene ID

861 (RUNX1), 12394 (Runx1), 50662

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of RUNX1 antibody

RUNX1 belongs to the runt domain family of transcription factors and regulates target gene expression through forming a heterodimeric DNA-binding complex with CBFB. RUNX1 was first identified as a RUNX1-ETO fusion protein in acute myeloid leukaemia (AML) and is frequently mutated in AML and myelodysplastic syndrome due to chromosomal translocation. RUNX1-deficient mice fail to generate hematopoietic stem cells. RUNX1 regulates CD4 gene transcription during multiple stages of T cell development and represses the CD4 gene in CD4-CD8- (double negative) T cells. RUNX1 is also required for the differentiation of CD8+, Th17, and regulatory T cells. Impaired differentiation of megakaryocytes and decreased circulating platelet count was observed in the absence of RUNX1. These findings revealed that RUNX1 acts as a tumor suppressor for myeloid leukemia and is crucial for the development and terminal differentiation of several blood cell lineages.

General readings

Ghozi,M.C., et al., (1996) Proc. Natl. Acad. Sci. U.S.A. 93 (5), 1935-1940

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RUNX1 pSer435 antibody

Western blot analysis of extracts from 293 cells (Lane 2), HeLa cells (Lane 3) and HepG2 cells (Lane 4), using AML1 (Phospho-Ser435) Antibody AP55801PU-N. The lane on the left is treated with antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

RUNX1 pSer435 antibody

Western blot analysis of extracts from 293 cells (Lane 2), HeLa cells (Lane 3) and HepG2 cells (Lane 4), using AML1 (Phospho-Ser435) Antibody AP55801PU-N. The lane on the left is treated with antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €270.00
  Acris Antibodies GmbH

RUNX1 pSer276 antibody

Western blot analysis of extracts from Jurkat cells, using AML1 (Phospho-Ser276) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

RUNX1 pSer276 antibody

Western blot analysis of extracts from Jurkat cells, using AML1 (Phospho-Ser276) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

RUNX1 pSer303 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using AML1 (Phospho-Ser303) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

RUNX1 pSer303 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using AML1 (Phospho-Ser303) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

RUNX1 pSer435 antibody

Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 30', using AML1 (Phospho-Ser435) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

RUNX1 pSer435 antibody

Western blot analysis of extracts from HepG2 cells treated with PMA 125ng/ml 30', using AML1 (Phospho-Ser435) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

RUNX1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using AML1 (Ab-276) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

RUNX1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using AML1 (Ab-276) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

RUNX1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using AML1 (Ab-303) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €230.00
  Assay Biotech

RUNX1 antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using AML1 (Ab-303) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Assay Biotech

RUNX1 antibody

Western blot analysis of extracts from HepG2 cells, treated with PMA 125ng/ml 30', using AML1 (Ab-435) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

RUNX1 antibody

Western blot analysis of extracts from HepG2 cells, treated with PMA 125ng/ml 30', using AML1 (Ab-435) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

RUNX1 - human gene knockout kit via CRISPR

RUNX1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RUNX1 - human gene knockout kit via CRISPR

RUNX1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RUNX1 - human gene knockout kit via CRISPR

RUNX1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RUNX1 - human gene knockout kit via CRISPR

RUNX1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Runx1 - mouse gene knockout kit via CRISPR

Runx1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RUNX1 (transcript variant 2)

  Recombinant protein of human runt-related transcription factor 1 (RUNX1), transcript variant 2  
RUNX1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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