RWDD3 antibody

Principal name

RWDD3 antibody

Alternative names for RWDD3 antibody

RSUME, RWD domain-containing protein 3, RWD-containing sumoylation enhancer

SwissProt ID

A3KN24 (Bovin), P0C7N0 (Rat), Q6PBV4 (Danre), Q8VIL2 (Mouse), Q9Y3V2 (Human)

Gene ID

25950 (RWDD3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of RWDD3 antibody

RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune?inflammatory signals. RWDD3 increases Ikappabeta sumoylation and stability. In addition, RWDD3 inhibits TNF-alpha-induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Ikappabeta increased stability. RSUME-enhanced sumoylation of Ikappabeta leads to the inhibition of NF-kappabeta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

RWDD3 (C-term) antibody

Western blot analysis of RWDD3 in rat kidney tissue lysate with RWDD3 antibody at 1 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RWDD3 (N-term) antibody

Western blot analysis of RWDD3 in mouse kidney tissue lysate with RWDD3 antibody at 0.5 µg/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

RWDD3 antibody

Western Blot analysis of RWDD3 expression in transfected 293T cell line (H00025950-T01) by RWDD3 MaxPab polyclonal antibody.

Lane 1: RWDD3 transfected lysate(21.45 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

RWDD3 (transcript variant 2)

RWDD3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

RWDD3

RWDD3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

RWDD3

RWDD3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

RWDD3 293T Cell Transient Overexpression Lysate(Denatured)

RWDD3 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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