Ryanodine receptor 1 / RYR1 antibody

Principal name

Ryanodine receptor 1 / RYR1 antibody

Alternative names for Ryanodine receptor 1 / RYR1 antibody

RYDR, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle-type ryanodine receptor, Type 1 ryanodine receptor

SwissProt ID

E9PZQ0, F1LMY4, P11716 (Rabit), P16960 (Pig), P21817 (Human)

Gene ID

6261 (RYR1)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F)

Background of Ryanodine receptor 1 / RYR1 antibody

It is well established that cytosolic calcium (Ca2+) acts as a key second messenger in many intracellular pathways including syptic transmission, muscle contraction, hormol secretion, cell growth and proliferation.1,2 The primary intracellular Ca2+ storage/release organelle in most cells is the endoplasmic reticulum (ER) or the sarcoplasmic reticulum (SR) in striated muscle cells. The ER and SR contain two Ca2+ release channels families, the Inositol trisphosphate receptors (IP3Rs) and the Ryanodine receptors (RyRs). The Ryanodine receptor family consists of three different isoforms: The skeletal muscle isoform, Ryanodine Receptor type 1 (RyR1); the cardiac muscle isoform, Ryanodine Receptor type 2 (RyR2) and the brain isoform, Ryanodine Receptor type 3 (RyR3). The Ryanodine receptors are homotetrameric proteins generating a Ca2+ conducting channel . They play a key role in the mechanism of excitation-contraction coupling in striated muscle. Binding of Ryanodine to the Ryanodine Receptor causes to two major changes in the channel: a reduction in single-channel conductance and a marked increase in open state probability. The RyR1 is expressed predomintly in skeletal muscles and areas of the brain; the human RyR1 has at least three known altertive spliced variants. Several diseases are attributed to mutations in RyR1 gene: Central Core Disease (CCD), multi-minicore disease (MmD) and Malignt Hyperthermia (MH).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ryanodine Receptor antibody

Ryanodine Receptor Mouse IgG2b G-1 Purified Bov, Can, Hu, Ms, Por, Rt C, E, F, ICC/IF, WB
50 µg / €730.00
  Acris Antibodies GmbH

Ryanodine receptor 1 / RYR1 antibody

Western blot analysis of rat skeletal muscle lysates: 1. Anti-Ryanodine Receptor 1 antibody , (1:200). 2. Anti-Ryanodine Receptor 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Ryanodine receptor 1 / RYR1 antibody

Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane: Mouse brain tissue, Primary antibody: (RYR1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Ryanodine receptor 1 / RYR1 antibody

ELISA: Ryanodine Receptor 1 Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

Ryanodine receptor 1 / RYR1 antibody

Ryanodine receptor 1 / RYR1 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Ryanodine receptor 1 / RYR1 antibody

Ryanodine receptor 1 / RYR1 Rabbit Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

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