Ryanodine receptor 1 / RYR1 antibody

Principal name

Ryanodine receptor 1 / RYR1 antibody

Alternative names for Ryanodine receptor 1 / RYR1 antibody

RYDR, Skeletal muscle calcium release channel, Skeletal muscle ryanodine receptor, Skeletal muscle-type ryanodine receptor, Type 1 ryanodine receptor

SwissProt ID

E9PZQ0, F1LMY4, P11716 (Rabit), P16960 (Pig), P21817 (Human)

Gene ID

6261 (RYR1)

Available reactivities

Amph (Amphibian), Bov (Bovine), Can (Canine), Ft (Ferret), Fi (Fish), Hu (Human), Mky (Monkey), Ms (Mouse), Rb (Rabbit), Rt (Rat), Sh (Sheep), Prim (Primate), Por (Porcine)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Neutralisation (NEUT), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of Ryanodine receptor 1 / RYR1 antibody

It is well established that cytosolic calcium (Ca2+) acts as a key second messenger in many intracellular pathways including syptic transmission, muscle contraction, hormol secretion, cell growth and proliferation.1,2 The primary intracellular Ca2+ storage/release organelle in most cells is the endoplasmic reticulum (ER) or the sarcoplasmic reticulum (SR) in striated muscle cells. The ER and SR contain two Ca2+ release channels families, the Inositol trisphosphate receptors (IP3Rs) and the Ryanodine receptors (RyRs). The Ryanodine receptor family consists of three different isoforms: The skeletal muscle isoform, Ryanodine Receptor type 1 (RyR1); the cardiac muscle isoform, Ryanodine Receptor type 2 (RyR2) and the brain isoform, Ryanodine Receptor type 3 (RyR3). The Ryanodine receptors are homotetrameric proteins generating a Ca2+ conducting channel . They play a key role in the mechanism of excitation-contraction coupling in striated muscle. Binding of Ryanodine to the Ryanodine Receptor causes to two major changes in the channel: a reduction in single-channel conductance and a marked increase in open state probability. The RyR1 is expressed predomintly in skeletal muscles and areas of the brain; the human RyR1 has at least three known altertive spliced variants. Several diseases are attributed to mutations in RyR1 gene: Central Core Disease (CCD), multi-minicore disease (MmD) and Malignt Hyperthermia (MH).

General readings

Liu Z et al. Three-dimensional reconstruction of the recombinant type 3 ryanodine receptor and localization of its amino terminus. Proc Natl Acad Sci U S A 98:6104-9 (2001). PubMed PMID: 11353864
Chan SL et al. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons. J Biol Chem 275:18195-200 (2000). PubMed PMID: 10764737
Yamada KA et al. Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum. J Cardiovasc Pharmacol 36:14-21 (2000). PubMed PMID: 10892655
Moore RA et al. A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein and function. J Cell Biol 140:843-51 (1998). PubMed PMID: 9472036
Protasi F et al. Role of ryanodine receptors in the assembly of calcium release units in skeletal muscle. J Cell Biol 140:831-42 (1998). PubMed PMID: 9472035
Liu G & Pessah IN Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydryls. J Biol Chem 269:33028-34 (1994). PubMed PMID: 7806531
Chen SR et al. Positioning of major tryptic fragments in the Ca2+ release channel (ryanodine receptor) resulting from partial digestion of rabbit skeletal muscle sarcoplasmic reticulum. J Biol Chem 268:22642-9 (1993). PubMed PMID: 8226772
Airey JA et al. Three ryanodine receptor isoforms exist in avian striated muscles. Biochemistry 32:5739-45 (1993). PubMed PMID: 7684927
Walton PD et al. Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons. J Cell Biol 113:1145-57 (1991). PubMed PMID: 1645737
Airey JA et al. Identification and localization of two triad junctional foot protein isoforms in mature avian fast twitch skeletal muscle. J Biol Chem 265:14187-94 (1990). PubMed PMID: 2387846
General / background references:Olivares EB et al. Nonmammalian vertebrate skeletal muscles express two triad junctional foot protein isoforms. Biophys J 59:1153-63 (1991). PubMed PMID: 1873458

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ryanodine Receptor antibody

Ryanodine Receptor Mouse IgG2b G-1 Purified Bov, Can, Hu, Ms, Por, Rt C, E, F, ICC/IF, WB
50 µg / €730.00
  Acris Antibodies GmbH

Ryanodine receptor 1 / RYR1 antibody

Western blot analysis of rat skeletal muscle lysates: 1. Anti-Ryanodine Receptor 1 antibody , (1:200). 2. Anti-Ryanodine Receptor 1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Ryanodine receptor 1 / RYR1 antibody

ELISA: Ryanodine Receptor 1 Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

Ryanodine receptor 1 / RYR1 antibody

Ryanodine receptor 1 / RYR1 Rabbit Purified Hu C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Ryanodine receptor 1 / RYR1 antibody

Ryanodine receptor 1 / RYR1 Rabbit Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

5 Item(s)

per page
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