Ryanodine receptor 2 / RYR2 antibody

Principal name

Ryanodine receptor 2 / RYR2 antibody

Alternative names for Ryanodine receptor 2 / RYR2 antibody

Type 2 ryanodine receptor, Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel

SwissProt ID

B0LPN4 (Rat), E9Q401, P30957 (Rabit), Q92736 (Human)

Gene ID

6262 (RYR2)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of Ryanodine receptor 2 / RYR2 antibody

It is well established that cytosolic calcium (Ca2+) acts as a key second messenger in many intracellular pathways including syptic transmission, muscle contraction, hormol secretion, cell growth and proliferation. The primary intracellular Ca2+ storage/release organelle in most cells is the endoplasmic reticulum (ER) or the sarcoplasmic reticulum (SR) in striated muscle cells. The ER and SR contain two Ca2+ release channels families, the Inositol trisphosphate receptors (IP3Rs) and the Ryanodine receptors (RyRs). The Ryanodine receptor family consists of three different isoforms: The skeletal muscle isoform, Ryanodine Receptor type 1 (RyR1); the cardiac muscle isoform, Ryanodine Receptor type 2 (RyR2) and the brain isoform, Ryanodine Receptor type 3 (RyR3). The Ryanodine receptors are homotetrameric proteins. They play a key role in the mechanism of excitation-contraction coupling in striated muscle. Binding of Ryanodine to the Ryanodine Receptor causes to two major changes in the channel: a reduction in single-channel conductance and a marked increase in open state probability. RyR2 serves as an intracellular Ca2+ channel in the SR membrane. It is predomintly expressed in cardiac muscle where it plays a central role in cardiac excitation-contraction coupling. RyR2 is also expressed in the brain.

General readings

This product has been used in:Du GG et al. Functional characterization of mutants in the predicted pore region of the rabbit cardiac muscle Ca(2+) release channel (ryanodine receptor isoform 2). J Biol Chem 276:31760-71 (2001). PubMed PMID: 11427530
Yamada KA et al. Long-chain acylcarnitine induces Ca2+ efflux from the sarcoplasmic reticulum. J Cardiovasc Pharmacol 36:14-21 (2000). PubMed PMID: 10892655
Lai FA et al. Amphibian ryanodine receptor isoforms are related to those of mammalian skeletal or cardiac muscle. Am J Physiol 263:C365-72 (1992). PubMed PMID: 1325114
General / background references:Moore RA et al. A transgenic myogenic cell line lacking ryanodine receptor protein for homologous expression studies: reconstitution of Ry1R protein and function. J Cell Biol 140:843-51 (1998). PubMed PMID: 9472036
Grunwald R & Meissner G Lumenal sites and C terminus accessibility of the skeletal muscle calcium release channel (ryanodine receptor). J Biol Chem 270:11338-47 (1995). PubMed PMID: 7744771
Carl SL et al. Immunolocalization of sarcolemmal dihydropyridine receptor and sarcoplasmic reticular triadin and ryanodine receptor in rabbit ventricle and atrium. J Cell Biol 129:672-82 (1995). PubMed PMID: 7730403
Junker J et al. Extended junctional sarcoplasmic reticulum of avian cardiac muscle contains functional ryanodine receptors. J Biol Chem 269:1627-34 (1994). PubMed PMID: 8294409
Xu L et al. Evidence for a Ca(2+)-gated ryanodine-sensitive Ca2+ release channel in visceral smooth muscle. Proc Natl Acad Sci U S A 91:3294-8 (1994). PubMed PMID: 8159742
McPherson PS & Campbell KP The ryanodine receptor/Ca2+ release channel. J Biol Chem 268:13765-8 (1993). PubMed PMID: 8390976

18 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ryanodine receptor 2 / RYR2 antibody

Western blot analysis of rat heart membranes: 1. Anti-Ryanodine Receptor 2 antibody , (1:200). 2. Anti-Ryanodine Receptor 2 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Ryanodine receptor 2 / RYR2 antibody

Immunohistochemistry analyzes of RyR2 antibody (Cat.-No.: AP20325PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €350.00
  Acris Antibodies GmbH

Ryanodine receptor 2 / RYR2 pSer2808 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using RyR2 (Phospho-Ser2808) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

Ryanodine receptor 2 / RYR2 pSer2808 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using RyR2 (Phospho-Ser2808) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

Ryanodine receptor 2 / RYR2 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using RyR2 (Ab-2808) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
50 µg / €205.00
  Assay Biotech

Ryanodine receptor 2 / RYR2 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using RyR2 (Ab-2808) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €310.00
  Assay Biotech

Ryanodine receptor 2 / RYR2 pSer2808 antibody

Immunohistochemical analysis of Ryanodine Receptor 2 (pS2808) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rb, Rt ICC/IF, P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

Ryanodine receptor 2 / RYR2 pSer2808 antibody

Immunohistochemical analysis of Ryanodine Receptor 2 (pS2808) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rb, Rt ICC/IF, P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

Ryanodine receptor 2 / RYR2 pSer2808 antibody

Immunohistochemical analysis of Ryanodine Receptor 2 (pS2808) staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rb, Rt ICC/IF, P, WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.

Ryanodine receptor 2 / RYR2 antibody

Western blot analysis of Ryanodine Receptor 2 expression in PC3 (A); MCF7 (B); NIH3T3 (C); mouse brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rb, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Ryanodine receptor 2 / RYR2 antibody

Western blot analysis of Ryanodine Receptor 2 expression in PC3 (A); MCF7 (B); NIH3T3 (C); mouse brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rb, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Ryanodine receptor 2 / RYR2 antibody

Western blot analysis of Ryanodine Receptor 2 expression in PC3 (A); MCF7 (B); NIH3T3 (C); mouse brain (D) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rb, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Ryanodine receptor 2 / RYR2 antibody

Immunofluorescence: Ryanodine Receptor 1 Antibody (C3-33) [NB120-2827] - Immunofluorescence with anti-Ryanodine Receptor Monoclonal Antibody [C3-33] (NB120-2827). Mouse IgG1 C3-33 Ascites Can C, F, ICC/IF, IP, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Ryanodine receptor 2 / RYR2 antibody

Ryanodine receptor 2 / RYR2 Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €420.00
  Novus Biologicals Inc.

Ryanodine receptor 2 / RYR2 antibody

Ryanodine receptor 2 / RYR2 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €360.00
  Novus Biologicals Inc.

Ryanodine receptor 2 / RYR2 antibody

Ryanodine receptor 2 / RYR2 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P
50 µg / €290.00
  Novus Biologicals Inc.

Ryanodine receptor 2 / RYR2 antibody

Immunohistochemistry-Paraffin: Ryanodine Receptor 2 Antibody [NBP1-90091] Immunohistochemical staining of human cerebral cortex shows distinct cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Ryanodine receptor 2 / RYR2 antibody

Immunohistochemistry-Paraffin: Ryanodine Receptor 2 Antibody [NBP1-90092] Immunohistochemical staining of human cervix, uterine shows strong cytoplasmic positivity in squamous epithelia, except for the basal layer. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

18 Item(s)

per page
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