Ryanodine receptor 3 / RYR3 antibody

Principal name

Ryanodine receptor 3 / RYR3 antibody

Alternative names for Ryanodine receptor 3 / RYR3 antibody

RYR-3, HBRR, Brain ryanodine receptor-calcium release channel, Brain-type ryanodine receptor

SwissProt ID

Q15413 (Human)

Gene ID

6263 (RYR3)

Available reactivities

Hu (Human), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of Ryanodine receptor 3 / RYR3 antibody

It is well established that cytosolic calcium (Ca2+) acts as a key second messenger in many intracellular pathways including syptic transmission, muscle contraction, hormol secretion, cell growth and proliferation. The primary intracellular Ca2+ storage/release organelles in most cells is the endoplasmic reticulum (ER) or the sarcoplasmic reticulum (SR) in striated muscle cells. The ER and SR contain two Ca2+ release channel families, the Inositol trisphosphate receptors (IP3Rs) and the Ryanodine receptors (RyRs). The Ryanodine receptor family consists of three different isoforms: The skeletal muscle isoform, Ryanodine Receptor type 1 (RyR1); the cardiac muscle isoform, Ryanodine Receptor type 2 (RyR2) and the brain isoform, Ryanodine Receptor type 3 (RyR3). The Ryanodine receptors are homotetrameric proteins generating a Ca2+ conducting channel. They play a key role in the mechanism of excitation-contraction coupling in striated muscle. Binding of Ryanodine (poisonous alkaloid found in the South American plant Ryania speciosa to the Ryanodine receptor causes two major changes in the channel: a reduction in single-channel conductance and a marked increase in the open state probability, leading to an overall increase/decrease in the Ca2+ release capability of the channel. RyR3 is the most widely expressed RyR channel which is predomintly expressed in smooth muscle tissues and certain regions of the brain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Ryanodine receptor 3 / RYR3 antibody

  Rabbit polyclonal Anti-Ryanodine Receptor 3  
Western blot analysis of rat brain membranes: 1. Anti-Ryanodine Receptor 3 antibody , (1:200). 2. Anti-Ryanodine Receptor 3 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

RYR3 - human gene knockout kit via CRISPR

RYR3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

RYR3 - human gene knockout kit via CRISPR

RYR3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

RYR3 - human gene knockout kit via CRISPR

RYR3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

RYR3 - human gene knockout kit via CRISPR

RYR3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

5 Item(s)

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