SAC3 antibody

Principal name

SAC3 antibody

Alternative names for SAC3 antibody

FIG4, KIAA0274, SAC domain-containing protein 3

SwissProt ID

Q91WF7 (Mouse), Q92562 (Human)

Gene ID

9896 (FIG4), 103199 (Fig4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of SAC3 antibody

Fig4/Sac3 phosphatase, a 97-kDa protein, specifically removes the 5-phosphate from the inositol ring of PI(3,5)P2, a membrane-bound phospholipid, which acts as a molecular signal for trafficking and fusion of intracellular vesicles. It is broadly expressed in all eukaryotic cells and plays a vital role in intracellular membrane trafficking and signaling. Mutations in Fig4/Sac3 have been linked to pale tremor mice that exhibit neuropathy with severe central and peripheral neuronal degeneration, including the loss of neurons in the dorsal root ganglion and the sciatic nerve. Fig4/Sac3 knockout mice have been shown to be smaller in size and exhibit abnormal tremor and gait and neuronal autophagy. Fig4/Sac3 deficiency is also reported to cause accumulation of cytoplasmic vacuoles in tissues, cultured fibroblasts, and neurons. Mutations in Fig4/Sac3 have been reported in patients with amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth Disease 4J that is characterized by severe motor dysfunction.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SAC3 antibody

Immunohistochemical staining of human duodenum shows strong positivity in glandular cells.This validation was performed by Protein Atlas and the presentation of data is for informational purposes only. Rabbit IgG Purified Hu E, ICC/IF, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

SAC3 antibody

Adult rat brain immunohistochemistry Mouse IgG1 N202/7 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SAC3 antibody

Adult rat brain membrane immunoblot Mouse IgG1 N202/7 Purified Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SAC3 antibody

Sample (30 ug of whole cell lysate). A: HCT116. 7.5% SDS PAGE. TA308985 diluted at 1:1000. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SAC3 (688-907) antibody

SAC3 Mouse IgG1 S202-7 Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €380.00
  Acris Antibodies GmbH

SAC3 antibody

Immunohistochemistry: FIG4 Antibody [26160002] - Most of the normal tissues displayed moderate to strong cytoplasmic positivity which was occasionally accompanied with nuclear staining. Malignant tissues exhibited in most cases moderate cytoplasmic immunoreactivity. Strong staining was observed in several tumors but was most prominent in colo-rectal and stomach cancers.  Image and statement courtesy of the Human Protein Atlas (HPA). Rabbit Hu E, P, WB
50 µg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SAC3

SAC3 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SAC3

SAC3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SAC3

SAC3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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