SASS6 antibody

Principal name

SASS6 antibody

Alternative names for SASS6 antibody

SAS6, HsSAS-6, Spindle assembly abnormal protein 6 homolog

SwissProt ID

O62479 (Caeel), Q5ZMV2 (Chick), Q6NRG6 (Xenla), Q6UVJ0 (Human), Q7ZVT3 (Danre), Q80UK7 (Mouse), Q9VAC8 (Drome)

Gene ID

163786 (SASS6)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of SASS6 antibody

SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle; it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SASS6 antibody

Western Blot analysis of SASS6 expression in transfected 293T cell line (H00163786-T01) by SASS6 MaxPab polyclonal antibody.

Lane 1: SASS6 transfected lysate(53.9 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SASS6 antibody

Western Blot: SAS-6 Antibody [NB100-93342] - Detection of Human SAS-6 by Western Blot of  Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP,  20% of IP loaded) from HeLa cells. Antibody: Affinity purified  rabbit anti-SAS-6 antibody NB100-93342 used for IP at 3 mcg/mg  lysate. SAS-6 was also immunoprecipitated by rabbit anti-SAS-6  antibody NB100-93343, which recognizes a downstream epitope Rabbit IgG Aff - Purified Hu IP
0.1 ml / €440.00
  Novus Biologicals Inc.

SASS6 antibody

WB and IP: SAS-6 Antibody [NB100-93343] - Detection of Human SAS-6 on HeLa whole cell lysate using NB100-93343. SAS-6 was also IPed by rabbit anti-SAS-6 antibody NB100-93342. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SASS6

SASS6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

SASS6

SASS6 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SASS6 293T Cell Transient Overexpression Lysate(Denatured)

SASS6 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

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