SATB1 antibody

Principal name

SATB1 antibody

Alternative names for SATB1 antibody

DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1

SwissProt ID

Q01826 (Human), Q60611 (Mouse)

Gene ID

6304 (SATB1)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of SATB1 antibody

Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a \'cage-like\' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a \'genome organizer\' essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.

General readings

Tan JA, Sun Y, Song J, Chen Y, Krontiris TG, Durrin LK. SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage. The Journal of biological chemistry 2008 Jun 283 (26): 18124-34. PMID: 18408014

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SATB1 antibody

  anti-SATB1 mouse monoclonal antibody, clone OTI13D6 (formerly 13D6)  
Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-SATB1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500522, Dilution 1:50) Mouse IgG1 OTI13D6 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

  anti-SATB1 mouse monoclonal antibody, clone OTI11H4 (formerly 11H4)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-SATB1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500523, Dilution 1:50) Mouse IgG1 OTI11H4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

  anti-SATB1 mouse monoclonal antibody, clone OTI4E1 (formerly 4E1)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-SATB1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500524, Dilution 1:50) Mouse IgG1 OTI4E1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

  anti-SATB1 mouse monoclonal antibody, clone OTI10G2 (formerly 10G2)  
Immunohistochemical staining of paraffin-embedded endometrium tissue within the normal limits using anti-SATB1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500552, Dilution 1:50) Mouse IgG1 OTI10G2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

  SATB1 mouse monoclonal antibody, clone OTI3E12 (formerly 3E12)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-SATB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500578) Mouse IgG1 OTI3E12 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

  SATB1 mouse monoclonal antibody, clone OTI11E8 (formerly 11E8)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-SATB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500589) Mouse IgG1 OTI11E8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

AP23696PU-N SATB1 Antibody staining of of paraffin embedded Human Thymus at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Hu, Ms, Rt E, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

SATB1 (C-term) antibody

  Rabbit Polyclonal SATB1 Antibody  
Western blot analysis of SATB1 in A20 cell lysate with SATB1 antibody at (A) 2 and (B) 4 µg/ml. Below: Immunohistochemistry of SATB1 in human brain with SATB1 antibody at 5 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SATB1 (N-term) antibody

  Rabbit Polyclonal SATB1 Antibody  
Western blot analysis of SATB1 in SK-N-SH cell lysate with SATB1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SATB1 antibody

  Rabbit anti-SATB1 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using SATB1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SATB1 antibody

  anti-SATB1 mouse monoclonal antibody, clone OTI6C6 (formerly 6C6)  
Anti-SATB1 mouse monoclonal antibody (TA500547) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SATB1(RC200421). Mouse IgG1 OTI6C6 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 (C-term) antibody

Human Thymus (formalin-fixed, paraffin-embedded) stained with SATB1 antibody AP22599PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

SATB1 - human gene knockout kit via CRISPR

SATB1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SATB1 - human gene knockout kit via CRISPR

SATB1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

SATB1 - human gene knockout kit via CRISPR

SATB1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

SATB1 - human gene knockout kit via CRISPR

SATB1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SATB1 (transcript variant 1)

  Recombinant protein of human SATB homeobox 1 (SATB1), transcript variant 1  
SATB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SATB1 (transcript variant 2)

  Recombinant protein of human SATB homeobox 1 (SATB1), transcript variant 2  
SATB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SATB1 (mGFP-tagged) - Human SATB homeobox 1 (SATB1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, SATB1 (mGFP-tagged) - Human SATB homeobox 1 (SATB1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SATB1 (mGFP-tagged)-Human SATB homeobox 1 (SATB1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, SATB1 (mGFP-tagged)-Human SATB homeobox 1 (SATB1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,710.00
  OriGene Technologies, Inc.

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