SATB1 antibody

Principal name

SATB1 antibody

Alternative names for SATB1 antibody

DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1

SwissProt ID

Q01826 (Human), Q60611 (Mouse)

Gene ID

6304 (SATB1), 5586304 (allB)

Available reactivities

Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Flow Cytometry (F), Frozen Sections (C)

Background of SATB1 antibody

Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma (By similarity). Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

General readings

Tan JA, Sun Y, Song J, Chen Y, Krontiris TG, Durrin LK. SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage. The Journal of biological chemistry 2008 Jun 283 (26): 18124-34. PMID: 18408014

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SATB1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-SATB1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500522, Dilution 1:50) Mouse IgG1 OTI13D6 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-SATB1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500523, Dilution 1:50) Mouse IgG1 OTI11H4 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-SATB1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500524, Dilution 1:50) Mouse IgG1 OTI4E1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

Immunohistochemical staining of paraffin-embedded endometrium tissue within the normal limits using anti-SATB1mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500552, Dilution 1:50) Mouse IgG1 OTI10G2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-SATB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500578) Mouse IgG1 OTI3E12 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-SATB1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500589) Mouse IgG1 OTI11E8 Purified Hu F, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 antibody

Immunohistochemistry-Paraffin: SATB1 Antibody (13D6) [NBP1-47950] - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of endometrium tissue using anti-SATB1mouse monoclonal antibody. (Dilution 1:50) Mouse 13D6 Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €620.00
  Novus Biologicals Inc.

SATB1 antibody

AP23696PU-N SATB1 Antibody staining of of paraffin embedded Human Thymus at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Hu, Ms, Rt E, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

SATB1 (C-term) antibody

Western blot analysis of SATB1 in A20 cell lysate with SATB1 antibody at (A) 2 and (B) 4 µg/ml. Below: Immunohistochemistry of SATB1 in human brain with SATB1 antibody at 5 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SATB1 (N-term) antibody

Western blot analysis of SATB1 in SK-N-SH cell lysate with SATB1 antibody at (A) 1 and (B) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SATB1 antibody

Western blot analysis of extracts of various cell lines, using SATB1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

SATB1 antibody

Anti-SATB1 mouse monoclonal antibody (TA500547) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY SATB1(RC200421). Mouse IgG1 OTI6C6 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SATB1 (C-term) antibody

Human Thymus (formalin-fixed, paraffin-embedded) stained with SATB1 antibody AP22599PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu, Ms, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SATB1 Control Peptide

SATB1
50 µg / €160.00
  Acris Antibodies GmbH

SATB1 Control Peptide

SATB1
50 µg / €160.00
  Acris Antibodies GmbH

SATB1 antibody

SATB1 Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SATB1 antibody

Immunohistochemistry of SATB1 in human brain with SATB1 polyclonal antibody ( Cat # PAB13379 ) at 5 µg/ml. Rabbit Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

SATB1 antibody

Western blot analysis of SATB1 in SK-N-SH cell lysate with SATB1 polyclonal antibody ( Cat # PAB13389 ) at ( A ) 1 and ( B ) 2 µg/ml. Rabbit Hu, Ms, Rt WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

SATB1 antibody

Transfected 293T; WB Suggested Anti-SATB1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Transfected 293T; SATB1 antibody - C-terminal region (ARP33362_P050) in Transfected 293T cells using Western Blot Rabbit Aff - Purified Chk, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

SATB1 antibody

SATB1 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

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