SAV1 antibody

Principal name

SAV1 antibody

Alternative names for SAV1 antibody

salvador homolog 1, WW45

SwissProt ID

A4V8B4 (Rat), Q8VEB2 (Mouse), Q9H4B6 (Human)

Gene ID

60485 (SAV1), 64010 (Sav1), 299116

Available reactivities

Hu (Human), Ms (Mouse)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of SAV1 antibody

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo sigling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kise cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and ictivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and termil differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptiol activity of ESR1 through the modulation of its phosphorylation.

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SAV1 antibody

  Rabbit Polyclonal Anti-SAV1 Antibody - C-terminal region  
WB Suggested Anti-Sav1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Brain Rabbit IgG Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

SAV1 antibody

  SAV1 mouse monoclonal antibody, clone OTI2B7 (formerly 2B7)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-SAV1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA804764) Dilution: 1:150 Mouse IgG1 OTI2B7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SAV1 antibody

  SAV1 mouse monoclonal antibody, clone OTI7C7 (formerly 7C7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SAV1 (RC204389, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SAV1. Mouse IgG1 OTI7C7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CRISPR

Catalog No. Species Donor Vector  

SAV1 - human gene knockout kit via CRISPR

SAV1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

SAV1 - human gene knockout kit via CRISPR

SAV1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sav1 - mouse gene knockout kit via CRISPR

Sav1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Sav1 - mouse gene knockout kit via CRISPR

Sav1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sav1 - mouse gene knockout kit via CRISPR

Sav1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Sav1 - mouse gene knockout kit via CRISPR

Sav1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SAV1

  Recombinant protein of human salvador homolog 1 (Drosophila) (SAV1)  
SAV1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

SAV1 overexpression lysate

SAV1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, SAV1 (mGFP-tagged) - Human salvador homolog 1 (Drosophila) (SAV1), 200 uL, >10^7 TU/mL

Lenti ORF particles, SAV1 (mGFP-tagged) - Human salvador homolog 1 (Drosophila) (SAV1), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, SAV1 (Myc-DDK tagged) - Human salvador homolog 1 (Drosophila) (SAV1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, SAV1 (Myc-DDK tagged) - Human salvador homolog 1 (Drosophila) (SAV1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Sav1 (GFP-tagged) - Mouse salvador homolog 1 (Drosophila) (Sav1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sav1 (GFP-tagged) - Mouse salvador homolog 1 (Drosophila) (Sav1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Sav1 (Myc-DDK-tagged) - Mouse salvador homolog 1 (Drosophila) (Sav1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sav1 (Myc-DDK-tagged) - Mouse salvador homolog 1 (Drosophila) (Sav1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Sav1 (GFP-tagged ORF) - Rat salvador homolog 1 (Drosophila) (Sav1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sav1 (GFP-tagged ORF) - Rat salvador homolog 1 (Drosophila) (Sav1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Sav1 (Myc-DDK-tagged ORF) - Rat salvador homolog 1 (Drosophila) (Sav1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Sav1 (Myc-DDK-tagged ORF) - Rat salvador homolog 1 (Drosophila) (Sav1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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