SAV1 antibody

Principal name

SAV1 antibody

Alternative names for SAV1 antibody

salvador homolog 1, WW45

SwissProt ID

A4V8B4 (Rat), Q8VEB2 (Mouse), Q9H4B6 (Human)

Gene ID

60485 (SAV1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Paraffin Sections (P)

Background of SAV1 antibody

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo sigling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kise cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and ictivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and termil differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptiol activity of ESR1 through the modulation of its phosphorylation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SAV1 antibody

Immunofluorescence of monoclonal antibody to SAV1 on HeLa cell. [antibody concentration 60 ug/ml] Mouse IgG2a 3B2 Purified Hu E, ICC/IF, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

SAV1 antibody

WB Suggested Anti-Sav1 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Brain Rabbit IgG Purified Hu, Ms WB
50 µg / €325.00
  OriGene Technologies, Inc.

SAV1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-SAV1 mouse monoclonal antibody. (Heat-induced epitope retrieval by Tris-EDTA, pH8.0, TA804764) Dilution: 1:150 Mouse IgG1 OTI2B7 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SAV1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SAV1 (RC204389, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SAV1. Mouse IgG1 OTI7C7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

SAV1 antibody

SAV1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

SAV1 antibody

Western Blot analysis of SAV1 expression in transfected 293T cell line (H00060485-T01) by SAV1 MaxPab polyclonal antibody.

Lane 1: SAV1 transfected lysate(42.13 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

SAV1 antibody

Immunoprecipitation of SAV1 transfected lysate using anti-SAV1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead (U0007), and immunoblotted with SAV1 MaxPab mouse polyclonal antibody (B01) (H00060485-B01). Rabbit Serum Hu E(detection), IP
0.1 ml / €380.00
  Abnova Taiwan Corp.

SAV1 antibody

Western Blot analysis of SAV1 expression in transfected 293T cell line (H00060485-T01) by SAV1 MaxPab polyclonal antibody.

Lane 1: SAV1 transfected lysate(44.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

SAV1 antibody

SAV1 monoclonal antibody (M04), clone 3A10. Western Blot analysis of SAV1 expression in Hela NE ( Cat # L013V3 ). Mouse IgG2a 3A10 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SAV1

SAV1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

SAV1

SAV1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SAV1

SAV1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Antibody Pairs

Catalog No.    

SAV1 (Human) IP-WB Antibody Pair

SAV1 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

SAV1 293T Cell Transient Overexpression Lysate(Denatured)

SAV1 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

SAV1 overexpression lysate

SAV1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

15 Item(s)

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