Sclerostin / SOST antibody

Principal name

Sclerostin / SOST antibody

SwissProt ID

Q99P67 (Rat), Q99P68 (Mouse), Q9BG79 (Bovin), Q9BQB4 (Human)

Gene ID

50964 (SOST), 74499 (Sost)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine)

Available hosts

Rabbit, Rat, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of Sclerostin / SOST antibody

Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bone homeostasis. Evidence is accumulating that one of the important mechanisms of bone regulation by sclerostin is the modulation of Wnt/Beta-catenin signaling. Sclerostin also rapidly activated ERK-1/2 MAPK signaling, indicating the involvement of additional signaling pathways

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Sclerostin / SOST (N-term) antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SOST antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Sclerostin / SOST antibody

Western blot analysis of extracts from Hela cells, using SOST Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Sclerostin / SOST (C-term) antibody

TA329666 (4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. Goat Aff - Purified Bov, Can, Hu, Ms, Rt E, P
0.1 mg / €325.00
  OriGene Technologies, Inc.

Sclerostin / SOST (Center) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Sclerostin / SOST antibody

Sclerostin / SOST Rat IgG2 4D77 Purified Ms WB
0.1 mg / €440.00
  Acris Antibodies GmbH

Sclerostin / SOST antibody

Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SOST polyclonal antibody ( Cat # PAB4841 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Sclerostin / SOST antibody

Sclerostin / SOST Rat IgG2 RM0129-4D77 Purified Ms WB
0.1 mg / €450.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Sclerostin / SOST

Sclerostin / SOST > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
10 µg / €139.00
  OriGene Technologies, Inc.

ELISA Kits

Catalog No.    

Mouse Sclerostin ELISA Kit

Representative Standard Curve  
96 Tests / €450.00
  Cohesion Biosciences Ltd.

Lysates

Catalog No.    

SOST overexpression lysate

SOST overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

10 Item(s)

per page
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