SCN1A antibody

Principal name

SCN1A antibody

Alternative names for SCN1A antibody

NAC1, SCN1, Sodium channel protein type 1 subunit alpha, Sodium channel protein type I subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.1, Sodium channel protein brain I subunit alpha

SwissProt ID

P04774 (Rat), P35498 (Human)

Gene ID

81574 (Scn1a), 6323 (SCN1A)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Vertebrates, Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of SCN1A antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing (3).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Nav1.1 antibody

Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Nav1.1 antibody

Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Nav1.1 antibody

Immunohistochemical analysis of Nav1.1 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SCN1A antibody

AP15783PU pan Sodium Channel antibody staining of Human Brain. Rabbit Purified Hu, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

SCN1A antibody

AP15783PU pan Sodium Channel antibody staining of Human Brain. Rabbit Purified Hu, Ms, Rt P
1 ml / €520.00
  Acris Antibodies GmbH

SCN1A antibody

AP15783PU pan Sodium Channel antibody staining of Human Brain. Rabbit Purified Hu, Ms, Rt P
0.1 ml / €190.00
  Acris Antibodies GmbH

SCN1A antibody

IHC analysis of Nav1.1 in frozen sections of mouse brain extract using the antibody Mouse IgG1 S74-71 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SCN1A antibody

Western blot analysis of rat brain membranes: 1. Anti-Nav1.1 antibody , (1:200). 2. Anti-Nav1.1 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SCN1A antibody

Western blot analysis of rat brain membranes: 1. Anti-Pan Nav antibody , (1:200). 2. Anti-Pan Nav antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SCN1A antibody

Anti-SCN1A / Nav1.1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Ze
50 µg / €379.00
  OriGene Technologies, Inc.

SCN1A antibody

Western blot analysis on HuvEc cell lysate using Sodium Channel-pan Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

SCN1A antibody

Whole brain immunohistochemistry Mouse IgG1 K74/71 Supernatant Hu, Ms, Rt C, ICC/IF, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SCN1A antibody

Whole brain immunohistochemistry Mouse IgG1 K74/71 Purified Hu, Ms, Rt C, ICC/IF, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

SCN1A antibody

Pancreas stained in IHC-P with SCN1A antibody Rabbit Purified Hu, Ms, Rt C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

SCN1A antibody

Immunohistochemical staining of Scn1a on formalin fixed, paraffin embedded human cerebellum with Scn1a polyclonal antibody. Rabbit Hu P, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

SCN1A antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using Sodium Channel-pan Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

SCN1A antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using Sodium Channel-pan Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

SCN1A antibody

SCN1A Rabbit Hu, Ms, Rt C, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

SCN1A antibody

SCN1A Rabbit IgG Hu P
7 ml / €380.00
  Novus Biologicals Inc.

SCN1A antibody

SCN1A Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

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