SCN2B antibody

Principal name

SCN2B antibody

Alternative names for SCN2B antibody

UNQ326/PRO386, Gm183, Sodium channel subunit beta-2

SwissProt ID

O60939 (Human), P54900 (Rat), Q56A07 (Mouse), Q864L3 (Canfa)

Gene ID

6327 (SCN2B), 25349 (Scn2b), 72821

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Can (Canine)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of SCN2B antibody

Voltage-gated sodium channels (V) are essential for the generation of action potentials and for cell excitability. To date, nine V α subunits have been cloned and med V1.1-V1.9.2,3 Mammalian sodium channels are heterotrimers, composed of a central, pore-forming α subunit and two auxiliary β-subunits (Vβ-subunit). The V β-subunit gene family consists of four members: β1 (SCN1B), β2 (SCN2B), β3 (SCN3B), and β4 (SCN4B) having type I topology, containing an extracellular amino-terminus, a single transmembrane segment, and an intracellular carboxyl-terminus.They modulate channel gating, assembly, and cell surface expression in heterologous cell systems. V β-subunits are cell adhesion molecules of the Ig superfamily, which interact with extracellular matrix, transmembrane sigling, and cell adhesion molecules. In the adult central nervous system and heart, sodium channels are associate with β1- β4 subunits, whereas in adult skeletal muscle they are associate only with the β1 subunit. This association appears to be a late event in sodium channel biosynthesis. Expression of β2-subunits increases in sensory neurons following nerve injury. β2 deficient mice develop less mechanical allodynia in compare to wild type mice, suggesting a role for β2 subunit in pain sensation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

SCN2B antibody

Western blot analysis of extracts from 293 cells, using SCN2B antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

SCN2B antibody

Western blot analysis of rat brain membranes under reducing (lanes 1 and 2) or non-reducing (lanes 3 and 4) conditions:* 1,3. Anti-Navβ2 antibody , (1:200). 2,4. Anti-Navβ2 antibody, preincubated with the control peptide antigen. * Navβ2 is disulfide-linked to the α subunit of voltage-gated Na+ channels (Schmidt, J.W., and Catterall, W.A. (1986) Cell 46, 437.) Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

SCN2B antibody

Immunoblot against crude membranes from adult rat brain (RBM) and wild-type (WT) and Navbeta2 knockout (KO) mouse brains probed with N395/68 (left) and N52A/42 (right) TC supe. Mouse brains courtesy of Lori Isom (University of Michigan). Mouse IgG1 N395/68 Supernatant Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

SCN2B (N-term) antibody

Brain, cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

SCN2B antibody

SCN2B Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

SCN2B antibody

Detection limit for recombinant GST tagged SCN2B is approximately 0.03ng/ml as a capture antibody. Mouse IgG1 2G11-C12 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

SCN2B antibody

SCN2B Rabbit Hu, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

SCN2B antibody

SCN2B Rabbit Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

SCN2B antibody

Western blot analysis of SCN2B expression in HEK293T (A); Raw264.7 (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

SCN2B antibody

Western blot analysis of SCN2B expression in HEK293T (A); Raw264.7 (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

SCN2B antibody

Western blot analysis of SCN2B expression in HEK293T (A); Raw264.7 (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

SCN2B antibody

Immunohistochemistry-Paraffin: Scn2b Antibody [NBP1-39493] - SCN2B antibody (20 ug/ml) was used in IHC to stain formalin-fixed, paraffin-embedded human brain, cortex, followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Rt E, P, WB
50 µg / €480.00
  Novus Biologicals Inc.

SCN2B antibody

Immunohistochemistry-Paraffin: Scn2b Antibody [NBP1-86091] - Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in neuronal cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

SCN2B (full length, N-term HIS tag)

SCN2B Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

SCN2B

SCN2B Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

SCN2B

SCN2B Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

16 Item(s)

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